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Dihydromyricetin
Myricetin
Luteolin
amygdalin
Chlorogenic acid
apigenin
Magnolia bark extract
magnolol
Honokiol
magnolol+honokiol
Macleaya cordata extract
sanguinarine
Chelerythrine
rosemary leaf extract
rosmarnic aicd
Carnosic acid
Ursolic acid
carnosic acid liquid oil
green coffee bean extract
honeysuckle flower extract
Banaba leaf extract
Loquat leaf extract
Fisetin
Polydatin
mangiferin
Betulin
huperzine a
Ferulic acid
Resveratrol

Magnolia bark extract  

Magnolia Officinalis Bark Extract 

Source: Magnolia bark

Latin Name:Magnolia officinalis.

Extract part: bark

Specifications: 1%-98%
Active Ingredient :magnolol,honokiol,magnolol+honikiol

CAS:magnolol:528-43-8,honokiol:35354-74-6,

magnolol+honokiol:1445684-99-0

Test Method:HPLC
Appearance: light yellow to off white powder

Magnolol and honokiol are the two main active ingredients of traditional Chinese medicine Magnolia, and have a wide range of pharmacological effects such as antibacterial, anti-inflammatory, anti-tumor muscle relaxation, cholesterol reduction and anti-aging. As early as 1930, Japan’s Sugiyra first isolated magnolol from the bark of Chinese magnolia, and proved that this ingredient is also contained in Japanese magnolia, but the amount is very low. In 1973, Fujita successively isolated magnolol and its isomers and magnolol from Japanese Magnolia and Magnolia.

 

Magnolia bark extract applications

 

Pharmaceutical use

The active component of magnolia officinalis extract is Magnolol and Honokiol,It can be used as an antibacterial agent (gram-negative bacteria and acid-resistant bacteria) and can be used to prevent and treat acne. 

Daily chemical use

The inhibition of Magnolol Honokiol on NF-cB cells proved to improve the function of skin immune cells and had anti-inflammatory effect.It can be used as the daily chemicals product such as toothphaste,mouthwash,shampoo ect.

Cosmetics use

The inhibition of Magnolol Honokiol on NF-cB cells proved to improve the function of skin immune cells and had anti-inflammatory effect. Magnolol Honokiol can also be used as an antioxidant and skin whitening agent.


Magnolia bark extract MOA and HPLC chromagram


                                                   Changsha Staherb Natural Ingredients Co.,Ltd.
 
Determination of Magnolol and Honokiol by HPLC 
 
1) Reagents
a. Nanopure water                   b. Methanol (HPLC)
 
2) Apparatus
HPLC (Shimadzu)                      Analytical balance (1/10000) 
 Ultrasonic cleaner                    0.45μm PTFE filter
50ml volumetric flask Screw      cap vials
 
3) HPLC condition
Column: Kromasil C18 5m 4.6×200mm
Detector: UV 294nm
Mobile Phase: A= water   B= MeOH
                     A:B=20:80(Isocratic)
Flow Rate: 1.0ml/min
Injection: 10μl
 
4) Procedure
Samples Preparation
Accurately weigh 30mg extraction into 50ml volumetric flask. Add MeOH to
volume and sonicate to mix, filter through a 0.45μm PTFE filter into a screw cap vial
and proceed with the analysis.
Standard preparation /calibration
Prepare a standard solution (approximately 0.2mg/ml in MeOH) using a standard of
MagnololSonicate for about 10 minutes and transfer to screw-cap vials and can be
stored in the refrigeration.
 
5) Calculation
Determine the peak areas of the Maglolol on the sample chromatogram and compare
to the corresponding peaks in the chromatogram for the standard solution. Calculate
the weight percent.

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