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Dihydromyricetin
Myricetin
Luteolin
amygdalin
Chlorogenic acid
apigenin
Magnolia bark extract
magnolol
Honokiol
magnolol+honokiol
Macleaya cordata extract
sanguinarine
Chelerythrine
rosemary leaf extract
rosmarnic aicd
Carnosic acid
Ursolic acid
carnosic acid liquid oil
green coffee bean extract
honeysuckle flower extract
Banaba leaf extract
Loquat leaf extract
Fisetin
Polydatin
mangiferin
Betulin
huperzine a
Ferulic acid
Resveratrol

Myricetin 

Bayberry extract myricetin

Source: Bayberry bark

Latin Name: Myrica rubra (Lour.) Sieb. et Zucc

Extract part: Bark

Specifications: 3%-98%

Active Ingredient :Myricetin

CAS:529-44-2

Test Method :HPLC

Appearance: Fine Light yellow powder 

Introduction:
Myricetin is a member of the flavonoid class of polyphenolic compounds, with antioxidant properties.
Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same  functions as these other members of the flavonol class of flavonoids.
The bulk of the medicinal attributes are located in the bark. This is due to its high concentration of flavonoids and tannins. Myricitrin is the primary flavonoid.
Although there are several species, Bayberry has been traced back to the Native American Indians where they used it for diarrhea, fever, uterine bleeding and tooth aches.
The colonists however did not focus on this herb's medicinal qualities but centered on its other properties for making candles, soaps and cosmetics.
Each country that utilizes this plant for medicinal purposes has its own primary use for it.
For example China favors it as an astringent and for the relief of pain, while Taiwan will recommend it for stomach disorders and diarrhea.
Aside from its medicinal properties, bayberry is a beneficial ingredient in some cosmetics and is a favorite for candle makers.
With its many potential benefits it should only be a matter of time until more extensive studies are conducted both in the medicinal and cosmetic fields.
 

Myricetin fuction andn applications

Application:

 

1. Eliminate free radical, antioxidation;

 

2. It has pharmacological action of anti-thrombus, anti-tumor, cardiac-cerebral vessels protection, dephlogisticate and antibiosis;

 

3. Relief alcoholic poisoning, liver protection etc;

 

4. Heat-clearing and detoxicating, eliminating rheumatism, bones and muscles enhancer;

 

5. Myricetin have the action of astringent, stimulant and emetic.

 

Function:

 

1.Reducing the levels of blood sugar:

Bayberry bark extract Myricetin has a good effect of reducing the levels of blood sugar.

 

 2.Anti-tumor:

Bayberry bark extract Myricetin has effective restrain to cell proliferation of some tumor cells.

 

3.Affecting the activation and proliferation of lymphocyte: 

Bayberry bark extract Myricetin can restrain the expression of CD69 which is the early activatory sign of T cells.

 

4.Low the neurotoxicity: 

Bayberry bark extract Myricetin can protect the neuron by restraining the neurotoxicity caused by Glutamic acid. Then it can hold neurotrosis effectively.

 

5.Antioxidation: 

Bayberry bark extract Myricetin Play a vital role on many neurologic disease such as ischaemia and Alzheimer’s disease through oxidative stress. It can reduce production and toxicity of the β-amylase.

 

6.Antagonism of platelet activiation factor(PAF): 

Bayberry bark extract Myricetin can restrain the gathering of WRP and release of 52HT caused by PAF. It can also restrain the rising of Serum ionized calcium in the platelet caused by PAF.

 

7.Protecting the liver:  

Bayberry bark extract Myricetin has the strong inhibitory action of the rise of ALT and AST in the blood Serum. It can low the total bilirubin in the blood serum. So myricetin has the strong action of lowing the aminotransferase and jaundice.

 MOA -Myrecetin

 

1Chromatographic conditions

 

Chromatographic column:Kromasil -C18 250cm×4.6mm 5μm Mobile phase: methanol: 0.03%H3PO4 Water (50∶50)

Column temperature:30℃

 

Flow rate:0.7.0mL/min

 

Detection wavelength:290nm

 

 

Injection volume:10μL

 

2Solution preparation

1. Preparation of reference solution Precision weighed dry to constant weight reference substance about 5mg in a 25 mL volumetric flask,Dissolve with methanol。

 

2. Preparation of Sample Solution accurately weighed extract samples about 80mg in 50mL volumetric flask add 30mL methanol,Ultrasonic oscillation 20min, Placed to room temperature,with Methanol to volume,filtered through a 0.45μm mmicroporous membrane,then get the obtain a sample solution。

 

3DETERMINATION OF SAMPLES

In the chromatographic conditions, injection determination after stable instrument, baseline is stable

 

 

4.Result          

                          A × Ws × S       ×100    

         Assay%=       As × W     

      ----As     Reference substance peak area

     ----A     Total peak area in the sample of myricetin

     ---Ws    Sample volume of Reference sample(mg)

     ---W    Sample weight of the sample(mg)

      ---S     Reference substance purity


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