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Chlorogenic acid 

 

Eucommia leaf extract chlorogenic acid

Source: Eucommia Leaf

Latin Name :Eucommia Ulmoides

Active Ingredient :Chlorogenic acid

CAS:327-97-9

Extract part: Leaf

Specifications: 3%-98%

Test Method :HPLC
Appearance: Fine white powder 

 

Chlorogenic acid Intruduction 

Eucommia has been widely cultivated in East Asian countries for its reported health properties in both its leaves and bark. In fact, this rare and unusual tree is second only to ginseng in traditional Chinese healthcare practices, where it is thought to be a longevity herb that helps restore balance to the body. The leaves are believed to help support healthy blood pressure already within a normal range. In animal feed supplement area, Eucommia leaf extract is believed to improve animal digestibility and health, decrease blood fat and has a broad-spectrum antimicrobial,anti-stress, antioxidant, free radical scavenging ability, it can also enhance immunity of animal .

 

Eucommia chlorogenic acid has function of antibacterial, anti-inflammatory, detoxification,choleretic,release of blood pressure, elevated white blood cells and a significant increase in gastric peristalsis and the promotion of secretion of gastric juice. Also has strong inhibition to escherichia coli, staphylococcus aureus, pneumococcal and viral, significant effects in acute throat inflammation and skin disease. Clinically for the treatment of acute bacterial infections and leucopenia caused by chemotherapy. it has good hemostatic effect on menorrhagia and functional uterine bleeding. its main pharmacological effects are:antihypertensive effect, anti-tumor, invigorate the kidney, strengthen the immune, antioxidant, anti-aging, anti-aging of muscle and skeleton, antibacterial, antiviral and so on.

Chlorogenic acid application & function

Function:

 

1.Reduce blood press with non-toxic and no side effects

2.It has the function of anti-cancer and anti-tumor

3.It has the effect of exciting pituitary-adrenal system and enhanceing the fuction of the adrenal cortex.

4.Promot metabolism and prevent aging.

 

 

Application:

 

1.  Applied in food field, eucommia tea get widespread concern when it come on the market;

2. Applied in health product field, to be added into the capsules, helping the body antibacterial and antiviral, regulating immunity;

3. Applied in pharmaceutical field, to be used as raw materials to reduce blood pressure.

4.Applied in feed additives

 

Chlorogenic aicd  HPLC chromatogram

References:

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13.Eskin, M. M. A., Hochn, E., and Frenkel, C. (1978) A simple and rapid quantitative method for total phenols. J. Agric. Food Chem. 26, 973–975.
14.Chlorogenic Acids
Small quantities of free quinic acid occur in green coffee beans. A greater quantity of quinic acid occurs as a series of esters (collectively) generally known as chlorogenic acids (CGA). Possibly the first repor...
M. N. Clifford in Coffee (1985)
15.Determination of baicalin, chlorogenic acid and forsythin in Chinese medicinal preparation by capillary electrophoresis
Xiangjun Li, Yuping Zhang, Zhuobin Yuan in Chromatographia (2002)
16.Isolation of Chlorogenic Acid from Flaveria bidentis (L.) Kuntze by CCC and Synthesis of Chlorogenic Acid-Intercalated Layered Double Hydroxide
Preparative counter-current chromatography (CCC) was successfully used for isolation and purification of chlorogenic acid from Flaveria bidentis (L.) Kuntze with a solvent system composed of ethyl acetate–methano...
Yun Wei, Yali Gao, Qianqian Xie, Guoliang Zhang, Weidong Fu in Chromatographia (2011)
17.Validation of an isocratic HPLC method based on the use of ABZ+ plus phase for the simultaneous determination of methylxantines, chlorogenic acid, some hydroxy-benzoic and hydroxy-cinnamic acids. Application to cocoa, coffee, tea and cola-drinks
M. Arlorio, J. D. Coïsson, A. Martelli in Chromatographia (2001)
18.The effect of post-exercise caffeine and chlorogenic acid supplementation on blood glucose disposal and insulin sensitivity
Jason R Beam, Ann L Gibson, Chad M Kerksick… in Journal of the International Society of Sp… (2013)
19.Correction to: Antiacetylcholinesterase activity and docking studies with chlorogenic acid, cynarin and arzanol from Helichrysum stoechas (Asteraceae)
The original version of this article unfortunately contained an error in the article title. There is a incorrect term Lamiaceae inadvertently appeared in the title, instead it should be Asteraceae.
Letícia Silva, Ana Margarida Rodrigues, Marina Ciriani… in Medicinal Chemistry Research (2018)

20.Correction to: the Inhibitory Effect of Chlorogenic Acid on Lipid Oxidation of Grass Carp (Ctenopharyngodon idellus) during Chilled Storage
The original version of this article unfortunately contained some mistakes.

Qiongju Cao, Hongying Du, Yuan Huang, Yang Hu, Juan You… in Food and Bioprocess Technology (2020)

21.Effect of Photoperiod and Chlorogenic Acid on Morphogenesis in Leaf Discs of Streptocarpus Nobilis
Leaf discs from vegetative plants greatly increase their phenolic content when cultivated in vitro. Under long days the values remained constant, and were higher when compared with short days cultures. Under shor...

E.I.S. Floh, W. Handro in Biologia Plantarum (2001)

22.Simultaneous determination of geniposidic acid, chlorogenic acid and geniposide in eucommia by HPLC
A high performance liquid chromatography (HPLC) method was established for simultaneous determination of geniposidic acid, chlorogenic acid and geniposide in eucommia. Detection at 240...3OH volume fraction, acidic

Yu-ping Li, Xiao-qing Chen, Mi-jun Peng… in Journal of Central South University of Tec… (2003)

23.Establishment of a simple method for purification of high purity chlorogenic acid from immature fruit of pear (Pyrus pyrifolia Nakai)
Chlorogenic acid [3-(3,4-dihydroxycinnamoyl)quinic acid, CGA] is one of the main...Pyrus pyrifolia...Nakai cv. Chuhwangbae) which contains CGA in high concentration. The 80 % MeOH extract (1.4 g) of immature pear...

Sang Won Lee, Yu Geon Lee, Jeong-Yong Cho… in Journal of the Korean Society for Applied … (2015)

24.Peroxidase activity against guaiacol, NADH, chlorogenic acid, ferulic acid and coniferyl alcohol in root tips of Lotus japonicus and L. corniculatus grown under low pH and aluminium stress
The purpose of this study was to examine the impact of low pH and Al stress on the apoplastic production of H2O2 and POD activity against guaiacol, ferulic acid, coniferyl alcohol, NADH and chlorogenic acid in th...

Veronika Zelinová, Igor Mistrík, Peter Paľove-Balang, Ladislav Tamás in Biologia (2010)

25.High-Performance Liquid Chromatographic Method for Determination and Pharmacokinetic Study of Chlorogenic Acid in the Plasma of Rats After Administration of the Chinese Medicinal Preparation Luying Decoction
A simple and sensitive high-performance liquid chromatographic method has been developed for determination of chlorogenic acid in rat plasma. Chlorogenic acid was extracted from plasma samples with methanol....18

Q. -F. Liao, Y. Jia, Q. -T. Gao, X. -H. Chen, X. -J. Tan, K. -S. Bi in Chromatographia (2005)

26.Photo-induced changes in the concentrations of individual chlorogenic acid isomers in potato (Solanum tuberosum) tubers and their complexation with ferric ions
Changes in the concentrations of 3-, 4- and 5-caffeoylquinic acids in potato tubers exposed to light have ... to 48 hours the observed increases in total chlorogenic acid content was due primarily to an increase ...

D. W. Griffiths, H. Bain in Potato Research (1997)

27.Validation of an isocratic HPLC method based on the use of ABZ+ plus phase for the simultaneous determination of methylxantines, chlorogenic acid, some hydroxy-benzoic and hydroxy-cinnamic acids. application to cocoa, coffee, tea and cola-drinks
Validation of an isocratic HPLC method for determination of methylxantines, chlorogenic acid and some hydroxy-benzoic/cinnamic acids in nervine foods and beverages is described....+ Plus phase permitted complete ...

M. Arlorio, J. D. Coïsson, A. Martelli in Chromatographia (2000)

28.Simultaneous identification of rutin, chlorogenic acid and gallic acid in Moringa oleifera by densitometric high-performance thin-layer chromatography method
An HPTLC (high-performance thin-layer chromatography) method was carried out to develop a feasible, simple and accurate method for the estimation of exact concentration of flavonoids in Moringa oleifera. The simu...

Pravej Alam, Prawez Alam… in JPC – Journal of Planar Chromatography – M… (2020)

29.Shock effects on plants: Tannic acid and chlorogenic acid in yam roots
Les tanins de l'acide chlorogénique s'accumulent immédiatement après que les racines d'ignames ont été soumises à des chocs de 10 à 44 ϕ (0.6–2.66 kg/cm2), consistant en une pulsation de la pression comparable à ...

Sylvia A. Murray in Experientia (1971)

30.Large-scale cultivation of adventitious roots of Echinacea purpurea in airlift bioreactors for the production of chichoric acid, chlorogenic acid and caftaric acid
Adventitious roots of Echinacea purpurea...were cultured in airlift bioreactors (20 l, 500 l balloon-type, bubble bioreactors and 1,000 l drum-type bubble bioreactor) using Murashige and Skoog (MS) medium with 2 ...

Chun-Hua Wu, Hosakatte Niranjana Murthy, Eun-Joo Hahn… in Biotechnology Letters (2007)


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