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Source: Peants Shell 
Latin Name :R.odorata L.

Extract part: Shell

Specifications: 98%
Active Ingredient:luteolin

Test Method :HPLC
Appearance: Fine Light yellow powder


Luteolin is a natural flavonoid found in many plants. It has a variety of pharmacological activities, such as anti-inflammatory, anti-allergic, uric acid-lowering, anti-tumor, anti-bacterial, anti-viral, etc. It is mainly used for cough, expectorant, anti-inflammatory, uric acid-lowering, cardiovascular disease treatment, and treatment of "muscle atrophic spinal cord side". Sclerosing", SARS, hepatitis, etc.

Luteolin Function

1.Luteolin is a hypoglycemic agent and improves insulin sensitivity. By promoting healthy glucose levels it is good for type 2 diabetics. 

2.Acting as an antioxidant and protecting the body from dangerous free radicals;

3.. Externally luteolin can be used for skin

allergic/inflammatory disorders and for skin cancer prevention;

4. Luteolin is a promising agent for use in ophthalmology.

Luteolin Application

1.Applied in food field, Luteolin is often used as food additives;

2. Applied in health product field, Luteolin is made into capsules with the function of vasodilatation;

3.Applied in pharmaceutical field, Luteolin can play the role of inflammation;

4.Applied in cosmetic field, Luteolin is often made into the products of losing weight.

1、Chromatographic conditions
Chromatographic column:Agilent Tc
C18, 250mm×4.6mm
Mobile phase: methanol,Water (88:12,v/v)
Column temperature:30℃
Flow rate:1mL/min
Detection wavelength:210nm
Injection volume:10μL
2、Solution preparation
1. Preparation of reference solution Precision weighed dry to constant weight
reference substance about 5mg in a 25 mL volumetric flask , Dissolve with
2. Preparation of Sample Solution,accurately weighed extract samples in a
volumetric flask and add methanol,Ultrasonic oscillation 20min, Placed to
room temperature , with Methanol to volume , filtered through a 0.45μm
mmicroporous membrane,then get the obtain a sample solution。
In the chromatographic conditions, injection determination after
stable instrument, baseline is stable

Assay %                A x Ws x S

                         R=----------------- x 100

                      As x W

---- As Reference substance peak area
---- A Total peak area in the sample of Butelin
--- Ws Sample volume of Reference sample(mg)
--- W Sample weight of the sample(mg)
--- S Reference substance 

Luteolin HPLC Chromagram

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1.López-Lázaro M. Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem. 2009;9(1):31–59.

2.Lin Y, Shi R, Wang X, et al. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets. 2008;8(7):634–46.

3.Rao PS. Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: involvement of cell line-specific apoptotic mechanisms. Int J Cancer. 2012;130(11):2703–14.

4.Dajas F, Rivera-Megret F, Blasina F, et al. Neuroprotection by flavonoids. Braz J Med Biol Res. 2003;36:1612–20.

5.Wang J, He Y, Zhang W, et al. Advances in studies on pharmacological effects of luteolin. Chin Bull Life Sci. 2013;25(6):560–5.

6.Han W, Xing Y, Kang T. Advances in studies on biological activities of Luteolin. Yunnan J Tradit Chin Med Matera Med. 2010;31(4):60–2.

7.Ulubelen A, Miski M, Neuman P, et al. Flavonoids of Salvia tomentosa (Labiatae). J Nat Prod. 1979;42(4):261–3.

8.Zhao G, Qin GW, Wang J, et al. Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt. Neurochem Int. 2010;56(1):168–76.

9.Separation of a Mixture of Luteolin-7-rutinoside and Luteolin-7-neohesperidoside Isolated from Ligustrum vulgare L.
Simple and rapid TLC and column chromatographic methods have been established for separation of luteolin-7-rutinoside and luteolin- 7-neohesperidoside on polyamide. A flavonoid...Ligustrum vulgare L. HPLC analysi...

Pavel Mučaji, Milan Nagy, Tibor Liptaj… in JPC – Journal of Planar Chromatography – M… (2009)

10.7-O-Methilether luteolin
Natural Compounds (2013)

11.Isoorientin (Luteolin-6-C-β-glucopyranoside)
Natural Compounds (2013)

12.Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells
Both reactive oxygen- and nitrogen-derived reactive species play important roles in physiological and pathophysiological conditions. Flavones, luteolin and luteolin-7-O-glucoside along with a rich...Taraxacum off...

Chun Hu, David D. Kitts in Molecular and Cellular Biochemistry (2004)

13.Erratum to: Anti-inflammatory effects of luteolin and luteoloside from Taraxacum coreanum in RAW264.7 macrophage cells
Ah Young Lee, Sullim Lee, Hyun Young Kim, Sanghyun Lee… in Applied Biological Chemistry (2016)

14.Erratum to: Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice
Daniela Impellizzeri, Emanuela Esposito, Rosanna Di Paola… in Arthritis Research & Therapy (2016)

15.Quercimeritrin and luteolin 7-glucoside in some species of Dipsacaceae
G. N. Zemtsova, V. A. Bandyukova in Chemistry of Natural Compounds (1968)

16.Cinaroside (Luteolin-7-O-glucoside)
Natural Compounds (2013)
17.Dynamics of the accumulation of luteolin 7-glucoside in the leaves ofSalix acutifolia
V. L. Shelyuto, A. A. Kir'yanov, L. P. Smirnova… in Chemistry of Natural Compounds (1986)

18.Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo Glioblastoma is the deadliest brain tumor in humans. High systemic toxicity of conventional chemotherapies prompted the search for natural compounds for controlling glioblastoma. The natural flavonoids luteolin (...Mrinmay Chakrabarti, Swapan K. Ray in Apoptosis (2016)

19.Cynaroside and luteolin from Campanula persicifolia and C. rotundifolia
L. S. Teslov, S. V. Teslov in Chemistry of Natural Compounds (1972)

20.Erratum to: Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype
Correction to Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T. Luteolin triggers global changes in the microglial transcriptome...J Neuroinflammation 2010,...

Konstantin Dirscherl, Marcus Karlstetter, Stefanie Ebert… in Journal of Neuroinflammation (2012)

21.Erratum to: A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
Irene Paterniti, Daniela Impellizzeri, Rosanna Di Paola… in Journal of Neuroinflammation (2016)

Natural Compounds (2013)

Natural Compounds (2013)

24.Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: additive effects of IFN-β
The study is aimed to determine the role of luteolin (3',4',5,7-tetrahydroxyflavone), ... -1 was assessed in the culture supernatants. Luteolin reduced, in a dose-dependent manner, ... released by PBMCs in the cu...

Zohara Sternberg, Kailash Chadha, Alicia Lieberman… in Journal of Neuroinflammation (2009)

25.A study of the antioxidant and membranotropic activities of luteolin using different model systems
Luteolin, a water-insoluble 3′,4′,5 ... of the best-studied representatives of bioflavonoids. Luteolin is an essential food component for humans ... the antioxidant (free-radical scavenging) properties of luteolin

A. M. Popov, A. N. Osipov, E. A. Korepanova, O. N. Krivoshapko… in Biophysics (2016)

26.Inhibitory effects of luteolin isolated fromixeris sonchifolia hance on the proliferation of hepg2 human hepatocellular carcinoma cells
We investigated the anti-proliferative effects of luteolin and apigenin, isolated fromIxeris sonchifolia...Hance, on HepG2 human hepatocellular carcinoma cells. In MTT assay luteolin showed more efficient anti-pr...

Yee Su Bog, Lee Jung Hwa, Chung Hae Young, Im Kwang Sik… in Archives of Pharmacal Research (2003)

27.Evaluation of Luteolin in the Prevention of N-nitrosodiethylamine-induced Hepatocellular Carcinoma Using Animal Model System
Hepatocellular carcinoma (HCC) is one of the commonest tumors worldwide. The treatment of HCC is vital for disease diagnosis and prognosis, as the liver is the most important organ controlling metabolic functions...

K. Balamurugan, J. Karthikeyan in Indian Journal of Clinical Biochemistry (2012)

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