Product List Home Main Product Plant Extract Natural Ingredients Solution Contact Us Exhibition
Neohesperidin dihydrochalcone
Neohesperidin 95%
Naringin 95%-98%
citrus bioflavonoids
synephrine
Hesperidin
Naringenin
Diosmin
methyl hesperidin
naringin dihydrochalcone
Shikimic acid
Mangosteen extract
oleanolic acid
Camptothecin
Artemisinin
Swertimarin
baicalein
Baicalin
Berberine hydrochloride
Sulforaphane
Glucoraphanin
Phloretin
Phlorizin
nervonic acid
Siberian Ginseng Extract

citrus bioflavonoids 

Citrus Bioflavonoids

Item name:Citrus Bioflavonoids

Plant  Source:Citrus aurantium Synonyn
Appearance:Dark brown powder
Main specification:Neohesperidin and naringin
Used Herbal Part:peel
Test method:HPLC/UV

 

Citrus Bioflavonoid Introduction:
Citrus Bioflavonoids are bioflavonoids with obvious Biological Action extracted from citrus fruits. It has specific aromaticity and obvious pharmacological action.

Clinical research testified that Citrus Bioflavonoids is not only pharmacology gene but also important nutrition gene.

The common citrus bioflavonoids include: Apigenin, Hesperidin, Hesperitin, Naringenin, Naringin, Narirutin, Nobiletin , Quercetin , Rutin, Tangeretin, Tangeritin.

 

Citrus aurantium extract

Active

Ingredients

Specs

Test Method

Appearance

Solubility

Synephrine

6%-30%

HPLC

Brown-yellow powder

Slightly soluble

in water and

methanol

Hesperidin

10%-98%

HPLC

Yellow to light brown powder

Slightly soluble

in methanol

Hesperetin

10%-98%

HPLC

Yellow to dark brown powder

Slightly soluble

in water and

methanol

Neohesperidin

10%-98%

HPLC

Off-White or light

yellow powder

soluble in hot

water and

ethanol

Diosmin/

Hesperidin

9:1

HPLC

Grayish Yellow or 

yellow powder

Slightly soluble

in water

Citrus Bioflavonoids

10%-90%

HPLC

Brown-yellow powder

Slightly soluble

in water

Nobiletin

98%

HPLC

White Crystalline 

powder

soluble in hot

water and

ethanol

PMFs

(Polymethoxy

Flavones)

10%-98%

HPLC

Yellow to Brown

Partially soluble in hot water and ethanol

NHDC

98%

HPLC

White

soluble in water

Citrus

Polyphenols

10%-90%

HPLC

Yellow to Brown 

soluble in water

  

Citrus Bioflavonoid Benefits:
1.Antioxidant protection
Citrus bioflavonoids are potent antioxidants that help combat free radicals and work synergistically with vitamin C.4,7

2.Capillary strength
Studies have shown that certain citrus bioflavonoids may strengthen capillaries, and researchers believe that may be related to its ability to protect collagen.7

3.Circulatory health
Citrus bioflavonoids may also provide benefits to overall circulatory health.7

4.Immune support
Numerous studies have demonstrated the ability of citrus bioflavonoids to help support a healthy immune system and immune response.

 

Citrus Bioflavonoid Application: 

1. In medical field, as the raw materials of drugs for bacterial infections, sedative and anti-cancer,

2. In health products, as the product of sedative and boosting immune system

3. In cosmetic field, as the product of leisure and boosting immune system

 

For more product information pls contact email sales09@staherb.cn

 

Analysis

Specification

Results

Assay(Total flavones)

≥50.0%

52.3%

Physical & Chemical Control

 

Identification

Positive

Complies

Appearance

Brown-yellow Fine Powder

Complies

Odor

Characteristic

Complies

Mesh Size

80 mesh

Complies

Loss On Drying

≤5.0%

3.27%

Methanol

≤5.0%

0.032%

Ethanol

≤5.0%

0.143%

Residue on Ignition

≤5.0%

2.18%

 

Heavy Metal Testing

 

 

 

Heavy Metals

<20ppm

Complies

As

<2ppm

Complies

LEAD(Pb)

< 0.5PPM

0.22 ppm

MERCURY(Hg)

Not dectect

Complies

CADMIUM

< 1 PPM

0.25 ppm

COPPER

< 1 PPM

0.32 ppm

ARSENIC

< 1 PPM

0.11 ppm

Microbiological

 

 

Total Plate Count

<1000/gMax

Complies

Staphylococcus Aurenus

Not Detected

Negative

Pseudomonas

Not Detected

Negative

Yeast & Mold

<100/gMax

Complies

Salmonella

Negative

Negative

E. Coli

Negative

Negative

References:

 

  1. 1.

    Abraham P, Wilfred G, Cathrine: Oxidative damage to the lipids and proteins pf the lungs, testis and kidney of rats during carbon tetrachloride intoxication. Clin Chim Acta. 1999, 289: 177-179. 10.1016/S0009-8981(99)00140-0.

  2. 2.

    Szymonik-Lesiuk S, Czechowska G, Stryjecka-Zimmer M, Slomka M, Madro A, Celinski K, Wielosz M: Catalase, superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication. J Hepatobiliary Pancreat Surg. 2003, 10: 309-315. 10.1007/s00534-002-0824-5.

  3. 3.

    Guven A, Guven A, Gulmez M: The effect of kefir on the activities of GSH-Px, GST, CAT, GSH and LPO levels in carbon tetrachloride-induced mice tissue. J Vet Med B Infect Dis Vet Public Health. 2003, 50: 412-416.

  4. 4.

    Ahmad FF, Cowan DL, Sun AY: Detection of free radical formation in various tissues after acute carbon tetrachloride administration in gerbil. Life Sci. 1987, 41: 2469-2475. 10.1016/0024-3205(87)90673-4.

  5. 5.

    Ohta Y, Nishida K, Sasaki E, Kongo M, Ishiguro I: Attenuation of disrupted hepatic active oxygen metabolism with the recovery of acute liver injury in rats intoxicated with carbon tetrachloride. Res Commun Mol Pathol Pharmacol. 1997, 95: 191-207.

  6. 6.

    Ozturk F, Ucar M, Ozturk IC, Vardi N, Batcioglu K: Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats. Urology. 2003, 62: 353-356.

  7. 7.

    Perez AJ, Courel M, Sobrado J, Gonzalez L: Acute renal failure after topical application of carbon tetrachloride. Lancet. 1987, 1: 515-516.

  8. 8.

    Churchill DN, Finn A, Gault M: Association between hydrocharbon exposure and glomerulonephritis.An araisal of the evidence. Nephron. 1983, 33: 169-172.

  9. 9.

    Ruprah H, Mant TGK, Flanagan RJ: Acute carbon tetrachloride poisoning in19 pateints: implications for diagnosis and treatment. Lancet. 1985, i: 1027-1029. 10.1016/S0140-6736(85)91624-1.

  10. 10.

    Yoshikawa T, Furukawa Y, Murakami M, Takemura S, Kondo M: Effect of viatmin E on D-Galactosamine-induced or carbon tetrachloride-induced hepatotoxicity. Digestion. 1982, 25: 222-229.

  11. 11.

    Ko KM, Ip SP, Poon MK, Wu SS, Che CT, Ng KH, Kong YC: Effect of a lignan-enriched fructus schisandrae extract on hepatic glutathione status in rats: protection against carbon tetrachloride toxicity. Planta Med. 1995, 61: 134-137. 

  12. 12.

    Garg A, Garg S, Zaneveld LJ, Singla AK: Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res. 2001, 15: 655-669. 10.1002/ptr.1074.

  13. 13.

    Jovanovic SV, Steenken S, Tosic M, Marjanovic B, Simic MG: Flavonoids as anti-oxidants. J Am Chem Soc. 1994, 116: 4846-4851.

  14. 14.

    Fraga CG, Martino VS, Ferraro GE, Coussio JD, Boveris A: Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence. Biochem Pharmacol. 1987, 36: 717-720. 10.1016/0006-2952(87)90724-6. 

  15. 15.

    Miller NJ, Rice-Evans CA: The relative contribution of ascorbic acid and phenolic antioxidants to the total antioxidant activity of orange and apple fruit juices and balckcurrant drink. Food Chem. 1997, 60: 331-337. 10.1016/S0308-8146(96)00339-1.

  16. 16.

    Suarez , Herrera MD, Marhuenda E: In vitro scavenger and antioxidant properites of hesperidin and neohesperidin dihydrochalcone. Phytomedicine. 1998, 5: 469-473.

  17. 17.

    Recknagel RO: Carbon tetrachloride hepatotoxicity: Status quo and future prospects. TIPS. 1983, March: 129-131.

  18. 18.

    Recknagel RO, Ghoshal AK: Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity. Lab Invest. 1966, 15: 132-148.

  19. 19.

    Durk H, Frank H: Carbon tetrachloride metabolism in vivo and exhalation of volatile alkanes: dependence upon oxygen parital pressure. Toxicology. 1984, 30: 249-257. 10.1016/0300-483X(84)90096-9.

  20. 20.

    Mansuy D, Fontecane M, Chottard J: A heme model study of carbon tetrachloride metabolism: mechanism of phosgene and carbon dioxide formation. Biochem Biophys Res Commun. 1980, 95: 1536-1542.

  21. 21.

    Pohl L, Schulick R, George J: Reductive oxygenation mechanism of metabolism of carbon tetrachlorideto phosgene by cytochrome P450. Mol Pharmacol. 1984, 25: 318-324.

  22. 22.

    Pohl L, Schulick R, Highet R, George J: Identification of dichloromethyl carbene as a metabolite of carbon tetrachloride. Biochem Biophys Res Commun. 1983, 117: 367-372. 10.1016/0006-291X(83)91209-3.

  23. 23.

    Tom WM, Fong D, Woo D, Prasongwatana V, Boyde TR: Microsomal lipid peroxidation and oxidative metabolism in rat liver. Chem Biol Interact. 1984, 50: 361-10.1016/0009-2797(84)90043-7.

  24. 24.

    Slater TF: Free-radical mechanisms in tissue injury. Biochem J. 1984, 222: 1-15.

  25. 25.

    Recknagel RO, Glende EA, Lowery K: Lipid peroxidation: Biochemisry, measurement and significance in liver cell injury. Toxicology of the Liver. Edited by: Plaa GL and Hewitt W. 1982, New York, Raven Press, 213-242.

  26. 26.

    ElSisi AE, Earnest DL, Sipes IG: Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species. Toxicol Appl Pharmacol. 1993, 119: 295-301. 

  27. 27.

    Hsiao G, Shen MY, Lin KH, Lan MH, Wu LY, Chou DS, Lin CH, Su CH, Sheu JR: Antioxidative and hepatoprotective effects of Antrodia camphorata extract. J Agric Food Chem. 2003, 51: 3302-3308. 

  28. 28.

    Jeong TC, Kim HJ, Park J, Ha CS, Park JD, Kim S, Roh JK: Protective effects of red ginseng saponins against carbon tetrachloride-induced hepatotoxicity in sprague dawley rats. Planta Med. 1996, 63: 136-140. 

  29. 29.

    Zimmerman SW, Norback DH, Powers K: Carbon tetrachloride nephrotoxicity in rats with reduced renal mass. Arch Pathol Lab Med. 1983, 107: 264-269.

  30. 30.

    Ogawa M, Mori T, Mori Y, Ueda S, Azemoto R, Makino Y, Wakashin Y, Ohto M, Wakashin M, Yoshida H, et al.: Study on chronic renal injuries induced by carbon tetrachloride: selective inhibition of the nephrotoxicity by irradiation. Nephron. 1992, 60: 68-73.

  31. 31.

    Fadhel ZA, Amran S: Effects of black tea extract on carbon tetrachloride-induced lipid peroxidation in liver, kidneys, and testes of rats. Phytother Res. 2002, 16 Suppl 1: S28-32. 10.1002/ptr.793.

  32. 32.

    Patil S, Kanase A, Varute AT: Effect of hepatoprotective ayurvedic drugs on lipases following CCl4 induced hepatic injury in rats. Indian J Exp Biol. 1989, 27: 955-958.

  33. 33.

    Miyake Y, Yamamoto K, Tsujihara N, Osawa T: Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids. 1998, 33: 689-695.

  34. 34.

    Jean T, Bodinier MC: Mediators involved in inflammation: effects of Daflon 500 mg on their release. Angiology. 1994, 45: 554-559.

  35. 35.

    Mandal AK, Sinha J, Mandal S, Mukhopadhyay S, Das N: Targeting of liposomal flavonoid to liver in combating hepatocellular oxidative damage. Drug Deliv. 2002, 9: 181-185. 10.1080/15227950290097615. 

  36. 36.

    IFCC methods for the measurement of catalytic concentrations of enzymes. part 3, IFCC. Method for alanine aminotransferase (l-alanine 2 -oxoglutarate aminotransferase, ec 2.6.1.2).

  37. 37.

    Pearlman FC, Lee RT: Detection and measurement of total bilirubin in serum, with use of surfactants as solubilizing agents. Clin Chem. 1974, 20: 447-453.

  38. 38.

    Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biocem. 1979, 95: 351-358. 10.1016/0003-2697(79)90738-3.

  39. 39.

    Jollow D, Mitchell L, Zampaglione N, Gillete J: Bromobenze induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzenoxide as the hepatotoxic intermediate. Pharmacol. 1974, 11: 151-169.

  40. 40.

    Kono Y: Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys. 1978, 186: 189-195. 10.1016/0003-9861(78)90479-4.

  41. 41.

    Claiborne A: Handbook of Methods for Oxygen Radical Reaserch. Edited by: Boca Raton FL. 1985, , CRC Press, 283-284.


Product List  |  Home  |  Main Product  |  Plant Extract  |  Natural Ingredients  |  Solution  |  Contact Us  |  Exhibition  |  Sitemap  |  Mobile Version
  English     简体版     繁體版
HomeContact UsSitemap