Product List Home Main Product Plant Extract Natural Ingredients Solution Contact Us Exhibition
Neohesperidin dihydrochalcone
Neohesperidin 95%
Naringin 95%-98%
citrus bioflavonoids
synephrine
Hesperidin
Naringenin
Diosmin
methyl hesperidin
naringin dihydrochalcone
Shikimic acid
Mangosteen extract
oleanolic acid
Camptothecin
Artemisinin
Swertimarin
baicalein
Baicalin
Berberine hydrochloride
Sulforaphane
Glucoraphanin
Phloretin
Phlorizin
nervonic acid
Siberian Ginseng Extract

Neohesperidin 95% 

Neohesperidin 95%

Product name:Neohesperidin

Latin Name: Citrus aurantium var. amara

Specifaction: 95%, 98%

Appearance: Off-White Powder 
Part Used: Fruit

Active Ingredients: Neohesperidin

Molecular Formula: C28H34O15

Molecular Weight: 610.56

CAS NO: 13241-33-3

Test Method: HPLC

 

Hesperidin is a flavanone glycoside found abundantly in citrus fruits. Its aglycone form is called hesperetin. Its name is derived from the Hesperides nymphs of Greek mythology. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies.

Synephrine is the main "active" compound found in the fruit of a plant called citrus aurantium. The fruit citrus aurantium is also known as zhi shi (in traditional Chinese medicine), and as green orange, sour orange and bitter orange in other parts of the world. Synephrine is chemically very similar to the e and pseudo-drine found in many OTC cold/allergy medications and in a number of weight loss and energy supplements which contain Ma Huang.

 Product Name  Neohesperidin
 Synonyms

 Hesperetin 7-neohesperidoside

 (S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

 (S)-4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]

 CAS  13241-33-3
 Molecular Formula  C28H34O15
 Molecular Weight   610.56
 Density  1.65 g/cm3
 Melting Point  239-243°C
 Boiling Point  933.7°C at 760 mmHg
 Flash Point  306.7°C
 Storage  2-8°C
 Refractive Index  1.695
 Appearance  Off-white powder
 Function

 1. Increased Metabolism

 2.Increase Fat Break Down

 3.Increased Thermogenesis

 4.Decreased Appetite

 5.Energy Increase

 6.Increase Fat Burning and Weight Loss

 7. A flavor enhancer and natural sweetener

 

 Application
1. As an active ingredient in dietary supplements
2. As an active ingredient in OTC and pharmaceutical field 
3. Pro-material of Neohesperidin Dihydrochalcone

 

Function

Be used to synthesize the Neohesperidin Dihydrochalcone

1) To treat hypertension

2)To reduce the brittleness of capillary and prevent microvascular bleeding

3)Infarction

 

 For more product information pls kindly contact email sales09@staherb.cn

 

Citrus aurantium extract

Active

Ingredients

Specs

Test Method

Appearance

Solubility

Synephrine

6%-30%

HPLC

Brown-yellow powder

Slightly soluble

in water and

methanol

Hesperidin

10%-98%

HPLC

Yellow to light brown powder

Slightly soluble

in methanol

Hesperetin

10%-98%

HPLC

Yellow to dark brown powder

Slightly soluble

in water and

methanol

Neohesperidin

10%-98%

HPLC

Off-White or light

yellow powder

soluble in hot

water and

ethanol

Diosmin/

Hesperidin

9:1

HPLC

Grayish Yellow or 

yellow powder

Slightly soluble

in water

     Citrus                Bioflavonoids

10%-90%

HPLC

Brown-yellow powder

Slightly soluble

in water

Nobiletin

98%

HPLC

White Crystalline 

powder

soluble in hot

water and

ethanol

PMFs

(Polymethoxy

Flavones)

10%-98%

HPLC

Yellow to Brown

Partially soluble in hot water and ethanol

NHDC

98%

HPLC

White

soluble in water

Citrus

Polyphenols

10%-90%

HPLC

Yellow to Brown 

soluble in water

References:

 

  1. 1.

    Montmayeur JP, Liberles SD, Matsunami H, Buck LB: A candidate taste receptor gene near a sweet taste locus. Nat Neurosci 2001, 4: 492–498.

  2. 2.

    Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Varadarajan V, Zou S, Jiang P, Ninomiya Y, Margolskee RF: Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 2003, 301: 850–853. 10.1126/science.1087155

  3. 3.

    Hoon MA, Adler E, Lindemeier J, Battey JF, Ryba NJ, Zuker CS: Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 1999, 96: 541–551. 

  4. 4.

    Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E: Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 2002, 99: 4692–4696. 10.1073

  5. 5.

    Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS: Mammalian sweet taste receptors. Cell 2001, 106: 381–390. 

  6. 6.

    Max M, Shanker YG, Huang L, Rong M, Liu Z, Campagne F, Weinstein H, Damak S, Margolskee RF: Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet 2001, 28: 58–63. 

  7. 7.

    Terrillon S, Bouvier M: Roles of G-protein-coupled receptor dimerization. EMBO Rep 2004, 5: 30–34.

  8. 8.

    Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS: An amino-acid taste receptor. Nature 2002, 416: 199–202. 

  9. 9.

    Brouwer JN, Hellekant G, Kasahara Y, van der Wel H, Zotterman Y: Electrophysiological study of the gustatory effects of the sweet proteins monellin and thaumatin in monkey, guinea pig and rat. Acta Physiol Scand 1973, 89: 550–557.

  10. 10.

    Sclafani A, Abrams M: Rats show only a weak preference for the artificial sweetener aspartame. Physiol Behav 1986, 37: 253–256. 10.1016/0031-9384(86)90228-3

  11. 11.

    Sclafani A, Perez C: Cypha [propionic acid, 2-(4-methoxyphenol) salt] inhibits sweet taste in humans, but not in rats. Physiol Behav 1997, 61: 25–29. 10.1016/S0031-9384(96)00316-2

  12. 12.

    Jiang P, Ji Q, Liu Z, Snyder LA, Benard LM, Margolskee RF, Max M: The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J Biol Chem 2004, 279: 45068–45075. 

  13. 13.

    Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X: Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Natl Acad Sci U S A 2004, 101: 14258–14263. 

  14. 14.

    Jiang P, Cui M, Zhao B, Snyder LA, Benard LM, Osman R, Max M, Margolskee RF: Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem 2005, 280: 34296–34305. 

  15. 15.

    Jiang P, Cui M, Zhao B, Liu Z, Snyder LA, Benard LM, Osman R, Margolskee RF, Max M: Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem 2005, 280: 15238–15246. 

  16. 16.

    Winnig M, Bufe B, Meyerhof W: Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor. BMC Neurosci 2005

  17. 17.

    Dogan M: Neohesperidin DC in food products: ; Trabzon, Türkiye. Volume 1. ; 2002:190–195.

  18. 18.

    DuBois GE, Crosby GA, Stephenson RA, Wingard RE Jr.: Dihydrochalcone sweeteners. Synthesis and sensory evaluation of sulfonate derivatives. J Agric Food Chem 1977, 25: 763–772. 

  19. 19.

    DuBois GE, Crosby GA, Stephenson RA: Dihydrochalcone sweeteners. A study of the atypical temporal phenomena. J Med Chem 1981, 24: 408–428. 10.1021

  20. 20.

    Durroux T: Principles: a model for the allosteric interactions between ligand binding sites within a dimeric GPCR. Trends Pharmacol Sci 2005, 26: 376–384. 

  21. 21.

    Morini G, Bassoli A, Temussi PA: From small sweeteners to sweet proteins: anatomy of the binding sites of the human T1R2_T1R3 receptor. J Med Chem 2005, 48: 5520–5529. 

  22. 22.

    Kratochwil NA, Malherbe P, Lindemann L, Ebeling M, Hoener MC, Muhlemann A, Porter RH, Stahl M, Gerber PR: An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application. J Chem Inf Model 2005, 45: 1324–1336. 

  23. 23.

    Whitelaw ML, Chung HJ, Daniel JR: Synthesis and sensory evaluation of ring-substituted dihydrochalcone sweeteners. 2. Analogues of 3'-Carboxyhesperetin dihydrocahlcone, a high-potency dihydrochalcone sweetener. J Agric Food Chem 1991, 39: 663–667. 

  24. 24.

    Whitelaw ML, Daniel JR: Synthesis and sensory evaluation of ring-substituted dihydrochalcone sweeteners. J Agric Food Chem 1991, 39: 44–51.

  25. 25.

    Naim M, Rogatka H, Yamamoto T, Zehavi U: Taste responses to neohesperidin dihydrochalcone in rats and baboon monkeys. Physiol Behav 1982, 28: 979–986. 10.1016/0031-9384(82)90163-9 

  26. 26.

    Bachmanov AA, Tordoff MG, Beauchamp GK: Sweetener preference of C57BL/6ByJ and 129P3/J mice. Chem Senses 2001, 26: 905–913. 10.1093

  27. 27.

    Ballesteros JA, H. W: Integrated Methods for the Construction of Three-Dimensional Models and Computational Probing of Structure-Function Relations in G-Protein-Coupled Receptors. Methods in Neuroscience 1995, 25: 366–428.

  28. 28.

    Bassoli A, Merlini L, Morini G: Isovanillyl sweeteners. From molecules to receptors. Pure Appl Chem 2002, 74: 1181–1187. 10.1351/pac200274071181

  29. 29.

    DuBois GE, Crosby GA, Saffron P: Nonnutritive sweeteners: taste-structure relationships for some new simple dihydrochalcones. Science 1977, 195: 397–399. 

  30. 30.

    Horowitz RM, Gentili B: Flavonoids of the Ponderosa lemon. Nature 1960, 185: 319. 

  31. 31.

    Schiffman SS, Booth BJ, Sattely-Miller EA, Graham BG, Gibes KM: Selective inhibition of sweetness by the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid. Chem Senses 1999, 24: 439–447. 10.1093

  32. 32.

    Hu J, McLarnon SJ, Mora S, Jiang J, Thomas C, Jacobson KA, Spiegel AM: A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+. J Biol Chem 2005, 280: 5113–5120. 10.1074

  33. 33.

    Malherbe P, Kratochwil N, Knoflach F, Zenner MT, Kew JN, Kratzeisen C, Maerki HP, Adam G, Mutel V: Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor. J Biol Chem 2003, 278: 8340–8347. 10.1074

  34. 34.

    Petrel C, Kessler A, Maslah F, Dauban P, Dodd RH, Rognan D, Ruat M: Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. J Biol Chem 2003, 278: 49487–49494. 

  35. 35.

    Pin JP, Galvez T, Prezeau L: Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol Ther 2003, 98: 325–354. 10.1016/S0163-7258(03)00038-X

  36. 36.

    Swaminath G, Deupi X, Lee TW, Zhu W, Thian FS, Kobilka TS, Kobilka B: Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J Biol Chem 2005, 280: 22165–22171. 10.1074

  37. 37.

    Hu J, Reyes-Cruz G, Chen W, Jacobson KA, Spiegel AM: Identification of acidic residues in the extracellular loops of the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ and a positive allosteric modulator. J Biol Chem 2002, 277: 46622–46631. 

  38. 38.

    Malherbe P, Kratochwil N, Zenner MT, Piussi J, Diener C, Kratzeisen C, Fischer C, Porter RH: Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine. Mol Pharmacol 2003, 64: 823–832.

  39. 39.

    Miedlich SU, Gama L, Seuwen K, Wolf RM, Breitwieser GE: Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site. J Biol Chem 2004, 279: 7254–7263. 

  40. 40.

    Pagano A, Ruegg D, Litschig S, Stoehr N, Stierlin C, Heinrich M, Floersheim P, Prezeau L, Carroll F, Pin JP, Cambria A, Vranesic I, Flor PJ, Gasparini F, Kuhn R: The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors. J Biol Chem 2000, 275: 33750–33758. 

  41. 41.

    Petrel C, Kessler A, Dauban P, Dodd RH, Rognan D, Ruat M: Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain. J Biol Chem 2004, 279: 18990–18997. 

  42. 42.

    Ray K, Tisdale J, Dodd RH, Dauban P, Ruat M, Northup JK: Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+). J Biol Chem 2005, 280: 37013–37020. 10.1074

  43. 43.

    Schaffhauser H, Rowe BA, Morales S, Chavez-Noriega LE, Yin R, Jachec C, Rao SP, Bain G, Pinkerton AB, Vernier JM, Bristow LJ, Varney MA, Daggett LP: Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol Pharmacol 2003, 64: 798–810. 

  44. 44.

    Ueda T, Ugawa S, Yamamura H, Imaizumi Y, Shimada S: Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells. J Neurosci 2003, 23: 7376–7380.


Product List  |  Home  |  Main Product  |  Plant Extract  |  Natural Ingredients  |  Solution  |  Contact Us  |  Exhibition  |  Sitemap  |  Mobile Version
  English     简体版     繁體版
HomeContact UsSitemap