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新橙皮甙二氫查爾酮Neohesperidin dihydrochalcone
新橙皮苷Neohesperidin 95%
柚皮苷Naringin 95%-98%
枳實黃酮citrus bioflavonoids
辛弗林synephrine
橙皮苷Hesperidin
柚皮素Naringenin
地奧司明Diosmin
甲基橙皮甙methyl hesperidin
柚皮苷二氫查耳酮naringin dihydrochalcone
莽草酸Shikimic acid
山竹提取物Mangosteen extract
齊墩果酸oleanolic acid
洗樹碱Camptothecin
青蒿素Artemisinin
獐芽菜苦甙Swertimarin
黃芩素baicalein
黃芩苷Baicalin
鹽酸小檗碱Berberine hydrochloride
蘿蔔硫素Sulforaphane
蘿蔔硫甙Glucoraphanin
根皮素Phloretin
根皮甙Phlorizin
元寶楓提取物神經酸nervonic acid
刺五加提取物Siberian Ginseng Extract

枳實黃酮citrus bioflavonoids 

枳實黃酮

品名:枳實黃酮

植物來源:Citrus aurantium Synonyn
顏色深棕色粉末
主要成分Neohesperidin and naringin
提取部位
檢測方式:HPLC/UV

枳實黃酮,由枳實中提取而得。具有抗氧化、抗菌與抗病毒、 與抗腫瘤、抗炎,調節免疫活性、治療心血管疾病、解毒護肝、影響內分泌和代謝等藥理作用。

 

【成分】

枳實中黃酮類化合物主要有橙皮有、柚皮苷、新橙皮苷、以及酸橙素、苦橙苷、枸桔苷、苦橙丁等。

【理化性質】

(1)黃酮類化合物多為結晶性固體,少數為無定形粉末。黃酮類化合物的分子結構中,大多帶有酚輕基,因此具有酚類化合物的通性。

(2)另外,分子中還常帶有毗酮環或碳基,構成了生色團的基本結構,根據羥基的數目,結合的位置與交叉共扼體系,構成了黃酮類化合物的呈色。黃酮、黃酮醇及其苷類多為灰黃至黃色雙氫黃酮、雙氫黃酮醇無交叉共軛體系一般不顯色;異黃酮類因共扼體系較短,顯微黃色花色素所顯顏色與有關,不同的條件下會呈現出紅、紫、藍等顏色。

(3)對於黃酮苷元,分子內含有不對稱碳原子的雙氫黃酮、雙氫黃酮醇、黃烷醇、雙氫異黃酮及其衍生物,具有旋光性,其餘苷元則無旋光性。黃酮苷類因結構中含有糖的分子,均含有旋光性,且多為左旋。

(4)黃酮類化合物的溶解度因結構及存在狀態苷或苷元,單糖苷,雙糖苷或三糖苷不同而有很大差異。一般游離苷元難溶于水,易溶于甲醇、乙醇、氯仿、乙酸乙酯等有機溶劑而黃酮苷一般易溶于水、甲醇、乙醇等極性溶劑,難溶或不溶于苯、氯仿等有機溶劑。

(5)黃酮類化合物多具有強的熒光,在紫外燈照射下呈亮黃、黃綠、亮藍、暗棕等顏色。

(6)黃酮類化合物對鹽酸鎂粉或汞齊呈鮮紅、紫色或黃色反應。結構中帶有3一OH,5一OH或鄰位羥基者,均能與金屬鹽類試劑如鋁鹽、鎂鹽、腮鹽、鐵鹽等形成顏色較深的絡合物。

產品詳詢:13657416805

參考文獻:

 

  1. 1.

    Abraham P, Wilfred G, Cathrine: Oxidative damage to the lipids and proteins pf the lungs, testis and kidney of rats during carbon tetrachloride intoxication. Clin Chim Acta. 1999, 289: 177-179. 10.1016/S0009-8981(99)00140-0.

  2. 2.

    Szymonik-Lesiuk S, Czechowska G, Stryjecka-Zimmer M, Slomka M, Madro A, Celinski K, Wielosz M: Catalase, superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication. J Hepatobiliary Pancreat Surg. 2003, 10: 309-315. 10.1007/s00534-002-0824-5.

  3. 3.

    Guven A, Guven A, Gulmez M: The effect of kefir on the activities of GSH-Px, GST, CAT, GSH and LPO levels in carbon tetrachloride-induced mice tissue. J Vet Med B Infect Dis Vet Public Health. 2003, 50: 412-416.

  4. 4.

    Ahmad FF, Cowan DL, Sun AY: Detection of free radical formation in various tissues after acute carbon tetrachloride administration in gerbil. Life Sci. 1987, 41: 2469-2475. 10.1016/0024-3205(87)90673-4.

  5. 5.

    Ohta Y, Nishida K, Sasaki E, Kongo M, Ishiguro I: Attenuation of disrupted hepatic active oxygen metabolism with the recovery of acute liver injury in rats intoxicated with carbon tetrachloride. Res Commun Mol Pathol Pharmacol. 1997, 95: 191-207.

  6. 6.

    Ozturk F, Ucar M, Ozturk IC, Vardi N, Batcioglu K: Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats. Urology. 2003, 62: 353-356.

  7. 7.

    Perez AJ, Courel M, Sobrado J, Gonzalez L: Acute renal failure after topical application of carbon tetrachloride. Lancet. 1987, 1: 515-516.

  8. 8.

    Churchill DN, Finn A, Gault M: Association between hydrocharbon exposure and glomerulonephritis.An araisal of the evidence. Nephron. 1983, 33: 169-172.

  9. 9.

    Ruprah H, Mant TGK, Flanagan RJ: Acute carbon tetrachloride poisoning in19 pateints: implications for diagnosis and treatment. Lancet. 1985, i: 1027-1029. 10.1016/S0140-6736(85)91624-1.

  10. 10.

    Yoshikawa T, Furukawa Y, Murakami M, Takemura S, Kondo M: Effect of viatmin E on D-Galactosamine-induced or carbon tetrachloride-induced hepatotoxicity. Digestion. 1982, 25: 222-229.

  11. 11.

    Ko KM, Ip SP, Poon MK, Wu SS, Che CT, Ng KH, Kong YC: Effect of a lignan-enriched fructus schisandrae extract on hepatic glutathione status in rats: protection against carbon tetrachloride toxicity. Planta Med. 1995, 61: 134-137. 

  12. 12.

    Garg A, Garg S, Zaneveld LJ, Singla AK: Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res. 2001, 15: 655-669. 10.1002/ptr.1074.

  13. 13.

    Jovanovic SV, Steenken S, Tosic M, Marjanovic B, Simic MG: Flavonoids as anti-oxidants. J Am Chem Soc. 1994, 116: 4846-4851.

  14. 14.

    Fraga CG, Martino VS, Ferraro GE, Coussio JD, Boveris A: Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence. Biochem Pharmacol. 1987, 36: 717-720. 10.1016/0006-2952(87)90724-6. 

  15. 15.

    Miller NJ, Rice-Evans CA: The relative contribution of ascorbic acid and phenolic antioxidants to the total antioxidant activity of orange and apple fruit juices and balckcurrant drink. Food Chem. 1997, 60: 331-337. 10.1016/S0308-8146(96)00339-1.

  16. 16.

    Suarez , Herrera MD, Marhuenda E: In vitro scavenger and antioxidant properites of hesperidin and neohesperidin dihydrochalcone. Phytomedicine. 1998, 5: 469-473.

  17. 17.

    Recknagel RO: Carbon tetrachloride hepatotoxicity: Status quo and future prospects. TIPS. 1983, March: 129-131.

  18. 18.

    Recknagel RO, Ghoshal AK: Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity. Lab Invest. 1966, 15: 132-148.

  19. 19.

    Durk H, Frank H: Carbon tetrachloride metabolism in vivo and exhalation of volatile alkanes: dependence upon oxygen parital pressure. Toxicology. 1984, 30: 249-257. 10.1016/0300-483X(84)90096-9.

  20. 20.

    Mansuy D, Fontecane M, Chottard J: A heme model study of carbon tetrachloride metabolism: mechanism of phosgene and carbon dioxide formation. Biochem Biophys Res Commun. 1980, 95: 1536-1542.

  21. 21.

    Pohl L, Schulick R, George J: Reductive oxygenation mechanism of metabolism of carbon tetrachlorideto phosgene by cytochrome P450. Mol Pharmacol. 1984, 25: 318-324.

  22. 22.

    Pohl L, Schulick R, Highet R, George J: Identification of dichloromethyl carbene as a metabolite of carbon tetrachloride. Biochem Biophys Res Commun. 1983, 117: 367-372. 10.1016/0006-291X(83)91209-3.

  23. 23.

    Tom WM, Fong D, Woo D, Prasongwatana V, Boyde TR: Microsomal lipid peroxidation and oxidative metabolism in rat liver. Chem Biol Interact. 1984, 50: 361-10.1016/0009-2797(84)90043-7.

  24. 24.

    Slater TF: Free-radical mechanisms in tissue injury. Biochem J. 1984, 222: 1-15.

  25. 25.

    Recknagel RO, Glende EA, Lowery K: Lipid peroxidation: Biochemisry, measurement and significance in liver cell injury. Toxicology of the Liver. Edited by: Plaa GL and Hewitt W. 1982, New York, Raven Press, 213-242.

  26. 26.

    ElSisi AE, Earnest DL, Sipes IG: Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species. Toxicol Appl Pharmacol. 1993, 119: 295-301. 

  27. 27.

    Hsiao G, Shen MY, Lin KH, Lan MH, Wu LY, Chou DS, Lin CH, Su CH, Sheu JR: Antioxidative and hepatoprotective effects of Antrodia camphorata extract. J Agric Food Chem. 2003, 51: 3302-3308. 

  28. 28.

    Jeong TC, Kim HJ, Park J, Ha CS, Park JD, Kim S, Roh JK: Protective effects of red ginseng saponins against carbon tetrachloride-induced hepatotoxicity in sprague dawley rats. Planta Med. 1996, 63: 136-140. 

  29. 29.

    Zimmerman SW, Norback DH, Powers K: Carbon tetrachloride nephrotoxicity in rats with reduced renal mass. Arch Pathol Lab Med. 1983, 107: 264-269.

  30. 30.

    Ogawa M, Mori T, Mori Y, Ueda S, Azemoto R, Makino Y, Wakashin Y, Ohto M, Wakashin M, Yoshida H, et al.: Study on chronic renal injuries induced by carbon tetrachloride: selective inhibition of the nephrotoxicity by irradiation. Nephron. 1992, 60: 68-73.

  31. 31.

    Fadhel ZA, Amran S: Effects of black tea extract on carbon tetrachloride-induced lipid peroxidation in liver, kidneys, and testes of rats. Phytother Res. 2002, 16 Suppl 1: S28-32. 10.1002/ptr.793.

  32. 32.

    Patil S, Kanase A, Varute AT: Effect of hepatoprotective ayurvedic drugs on lipases following CCl4 induced hepatic injury in rats. Indian J Exp Biol. 1989, 27: 955-958.

  33. 33.

    Miyake Y, Yamamoto K, Tsujihara N, Osawa T: Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids. 1998, 33: 689-695.

  34. 34.

    Jean T, Bodinier MC: Mediators involved in inflammation: effects of Daflon 500 mg on their release. Angiology. 1994, 45: 554-559.

  35. 35.

    Mandal AK, Sinha J, Mandal S, Mukhopadhyay S, Das N: Targeting of liposomal flavonoid to liver in combating hepatocellular oxidative damage. Drug Deliv. 2002, 9: 181-185. 10.1080/15227950290097615. 

  36. 36.

    IFCC methods for the measurement of catalytic concentrations of enzymes. part 3, IFCC. Method for alanine aminotransferase (l-alanine 2 -oxoglutarate aminotransferase, ec 2.6.1.2).

  37. 37.

    Pearlman FC, Lee RT: Detection and measurement of total bilirubin in serum, with use of surfactants as solubilizing agents. Clin Chem. 1974, 20: 447-453.

  38. 38.

    Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biocem. 1979, 95: 351-358. 10.1016/0003-2697(79)90738-3.

  39. 39.

    Jollow D, Mitchell L, Zampaglione N, Gillete J: Bromobenze induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzenoxide as the hepatotoxic intermediate. Pharmacol. 1974, 11: 151-169.

  40. 40.

    Kono Y: Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys. 1978, 186: 189-195. 10.1016/0003-9861(78)90479-4.

  41. 41.

    Claiborne A: Handbook of Methods for Oxygen Radical Reaserch. Edited by: Boca Raton FL. 1985, , CRC Press, 283-284.


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