Root bark glycosides
Molecular formula: C21H24O10
Molecular weight: 436.41
Molecular formula: C12H24O10.2H2O
Molecular weight: 472.45
Appearance: slightly yellow needle-like crystals
Solubility: very good water solubility at low content; poor water solubility at high content, easily soluble in ethanol, etc.
Roots, stems, bark and other parts of plants
Root bark glycosides have a variety of important biological activities such as lowering blood sugar, improving memory, antioxidant, anti-cancer, etc., and have wide application prospects in the development of new drugs and natural health food.
Rhizobioside is extracted from apples, apple bark and leaves, etc. It is a phenolic substance in apple tree, and research shows that rhizobioside accounts for 95% of the total phenolic content in apple tree, and its content is so high that its presence can affect the overall presence of phenolic substances. Rhizobioside is a glycoside formed by the combination of rhizobioside and the ligand for glucoside, and the hydrolysis of glycosyl group to form glucose, plus the high content, is considered by many scholars as a storage form of carbohydrates. 4-deoxyrhizobioside has also been widely studied and applied. Its degradation product, radicicol, can effectively inhibit the effect of microbial activity, etc.
Various flavonoids have some degree of action in eliminating free radicals such as superoxide anion Oˉ2-. This antioxidant ability is derived from the hydrogen or electron donating ability of their phenolic hydroxyl groups. Rhizobioside is a glycoside derivative of dihydrochalcone rhizobioside. Dihydrochalcone is a member of flavonoids and has certain antioxidant properties and antioxidant characteristics. Although the molecular structure of rhizobioside is weakened by hydroxyl glycosylation at the 2'-position, its overall antioxidant capacity is still higher than that of VC and VE, and it has a unique antioxidant mechanism. In addition, rhizobioside can be hydrolyzed in vivo to remove the glycosidic group to form rhizothelin, which has better antioxidant capacity.
It has anti-tumor activity and has therapeutic effect on skin cancer. It can be used in facial products to inhibit the formation of melanin and reduce the color of brown, gray and freckles.
Treatment of diabetes
Recent clinical studies at home and abroad have shown that root bark glycosides are effective in the treatment of diabetes mellitus. Many scientists have used root bark glycosides in the study of the pathogenesis of diabetes and in the exploration of treatment methods for diabetes, making it possible for research on the treatment of diabetes to proceed rapidly and smoothly.
The young leaves of apple and sweet tea are rich in phloridzin, and recent studies have found that phloridzin has some unique functions in the prevention and treatment of diabetes and its complications. A review of the research progress in this field at home and abroad is presented in order to provide some help for the development and utilization of phloridzin.
Root bark glycosides specifically and competitively inhibit the transport of glucose molecules by SGLT1 and SGLT2. It has been shown in several animal models that root bark glycosides can promote glucose secretion and lower fasting and postprandial glucose levels without hypoglycemic side effects. Treatment of diabetic rats with root bark glycosides restored their insulin sensitivity to normal and eliminated or reduced insulin resistance caused by glucotoxicity.
Stimulates sexual desire
Foreign media reported that a recent study by scientists found that women who ate one or more apples a day had a higher quality of sex than women who ate less than one apple, and that apples may be an "aphrodisiac". This is because apples contain a compound called "rhizosphingoside," which is very similar in function to "estradiol," the hormone that plays an important role in the process of sexual arousal. This is why regular consumption of apples can improve female sexual function.
Brain activity consumes a large amount of energy supplied by glucose, and there is much evidence that circulating blood glucose levels control learning and memory processes, and the effects of many memory improvement drugs are related to the ability to release liver glycogen and increase brain blood glucose levels and utilization. Root bark glycosides inhibit the entry of blood glucose into the brain. Thus the mechanism by which root bark glycosides enhance the brain's memory capacity is apparently independent of blood glucose levels or the brain's ability to absorb sugar.
Root bark glycosides can be used as antioxidants added to foods. Although its antioxidant property is not as good as that of oak spermidine, proanthocyanidins and chlorogenic acid in apple polyphenols, but because it has the effect of reducing high blood sugar, if it is used in functional foods, it can achieve the purpose of reducing high blood sugar and solve the problem of food oxidation at the same time.
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Business scope: Biotechnology, research and development of plant extracts (can be used in the field of pharmaceutical and health products, cosmetics, feed additives and biological pesticide production and development)
Main products: Eucommia extract - chlorogenic acid (5%-98%), ursolic acid (25%-98%), corosolic acid (1%-98%), bitter amygdalin (50%-98%), epimedoside (10%-98%) and other standardized high-purity plant extracts.
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