Corosolic acid is a white amorphous powder (methanol), also known as phytocerebrosides, 2α-hydroxyursolic acid, which belongs to α-coumarinol type or ustane type pentacyclic triterpenoids, soluble in petroleum ether, benzene, chloroform, pyridine and other organic solvents, insoluble in water, soluble in hot ethanol and methanol. Under anhydrous conditions, it shows color reaction or fluorescence when interacting with strong acid (sulfuric acid, phosphoric acid, perchloric acid), medium to strong acid (trichloroacetic acid) or Lewis' acid (zinc chloride, aluminum trichloride, antimony trichloride).
Corosolic acid is now a popular product in the market as a new phytopharmaceutical and functional natural health food pharmaceutical ingredient to combat obesity and type II diabetes. The natural product is currently marketed as a nutritional supplement in the U.S., along with a Phase III clinical trial for the treatment of diabetes, and will be approved by the FDA in the near future. The effect of its use in the treatment of diabetes is comparable to that of injected insulin, with the advantages of significant oral effect, less toxic side effects and ease of use, and the effect is comparable to that of injected insulin. The content of corosolic acid in plants is generally very low, even in V. grandiflora, which has a high content of corosolic acid, the content of corosolic acid is only about 0.01% in the concentrated extract of its hot water extraction; in the alcohol concentrated extract of Barnabas leaves, the content of corosolic acid is only about 1%. Microherb has successfully isolated high purity 98% corosolic acid using advanced chromatographic separation technology for use in experimental and clinical studies on the efficacy and toxicity of corosolic acid in the prevention and treatment of obesity and type II diabetes.
The main effects of corosolic acid are as follows: 1. It can regulate the insulin and blood glucose levels in the body and has a significant tendency to lose weight. It can be used for weight loss. 2. It has a significant hypoglycemic effect. 3. It has a significant inhibitory effect on inflammation, and its anti-inflammatory effect is stronger than that of commercially available anti-inflammatory drugs such as indomethacin. 4. It has an inhibitory effect on the growth of many kinds of tumor cells, and has a wide prospect in looking at this aspect.
Address: Room 202, Building B8, Huanchuang Enterprise Square, Lugu Street, Yuelu District, Changsha City, Hunan Province
Business scope: Biotechnology, research and development of plant extracts (can be used in the field of pharmaceutical and health products, cosmetics, feed additives and biological pesticide production and development)
Main products: Eucommia extract - chlorogenic acid (5%-98%), ursolic acid (25%-98%), corosolic acid (1%-98%), bitter amygdalin (50%-98%), epimedoside (10%-98%) and other standardized high-purity plant extracts.
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