The plant extract Chelidonium extract is the whole herb extract of ChelidoniummajusL., family Popaceae, containing a variety of alkaloids, mainly Chelidonium, chrysophanine, proto-opiomelanine, hematoxyline and so on. It has pharmacological activities such as analgesic, cough suppressant, anti-inflammatory, anti-cancer, antibacterial and choleretic.
Extracted from the whole herb of ChelidoniummajusL., family Popaceae.
Pharmacological effects 1. sedative, analgesic effect of Chelidonium have analgesic effects similar to , can significantly increase the threshold of nociception, analgesic effect can last 4 to 48 hours. There is a paralyzing effect on sensory nerve endings, and the response wave to electrical stimulation is prolonged in isolated neuromuscular specimens. The extract has a weak sedative and hypnotic effect on the center. The injection of C. leucocephala can significantly inhibit spontaneous activity in mice, and has a synergistic effect with sodium .2. Anticancer effect C. leucocephala has inhibited cancer activity and retarded the growth of malignant tumors. The methanolic extract of Leucospermum leucocephalum has a significant carcinogenic effect on mouse sarcoma 180 and mouse Ehrlich carcinoma. Chelerythrine and protopine also had tumor suppressive effects on murine sarcoma 180 and murine Ehrlich carcinoma. It has a good blocking effect on nitrosoguanidine-induced bone carcinoma in Wistar rats. The antispasmodic and antitussive effect of leucocarpus on esophageal cancer cells.3. The experiment with guinea pigs showed that leucocarpus can prevent the occurrence of anaphylaxis or histamine shock and has an antitussive effect on cough. The cough suppressant effect of chelerythrine, can be directly on the central nervous system of the cough center, and has antiparasympathetic and antihistamine activity. The intraperitoneal injection of aqueous decoction of Chelidonium can increase the bronchial excretion of phenol red in mice, with antihistamine bronchospasm effect and cough suppressant effect.4. Anti-inflammatory effect of blood root base subcutaneously, can have the effect of inhibiting the swelling of the toe of angularis gum in rats.5. Antibacterial, antiviral effect of Chelidonium red base and blood root base can inhibit the effect of Gram-positive bacteria and Pseudomonas alba. Leuconostoc can inhibit influenza virus in vivo and in vitro. The effect of leucocyte injection on smooth muscle has a relaxing effect on smooth muscle, and also has a significant effect on the relief of smooth muscle spasm, on antigen, histamine, cholagogues (such as maurethrine) and barium chloride It has obvious antagonistic effect on smooth muscle spasm induced by antigen, histamine, cholinomimetic (such as trichothecene) and barium chloride. The effect of leucovorin extract and leucovorin can increase small intestinal tone and decrease large intestinal tone in mice; inhibit the spontaneous collection of guinea pig isolated pregnant uterus. 7. β-Homochondroitin causes a transient drop in blood pressure, slows heart rate, and paralyzes the vasomotor center at high doses. 8. Anti-hepatotoxic activity The ethanolic extract of C. leucocephala provides effective protection against carbon tetrachloride-induced elevation of plasma ALAT, ASAT, and LDH; where ALAT is the marker enzyme. The protection against carbon tetrachloride-induced alkaline phosphatase activity was low.9. Cholestatic effectsThe total extract, phenolic components and alkaloids of C. leucocephala can promote bile secretion, increase bile flow and reduce bile acid content, which have significant cholestatic effects. The total extract of C. leucocephala produces cholestatic effects by increasing the non-dependent bile flow of bile acids.10. Other effects C. leucocephala aqueous decoction has the effect of enhancing leukocyte phagocytosis in mice. Chelerythrine can increase urinary excretion while retaining calcium and sodium ions; it can prevent or delay the appearance of anaphylaxis.
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Business scope: Biotechnology, research and development of plant extracts (can be used in the field of pharmaceutical and health products, cosmetics, feed additives and biological pesticide production and development)
Main products: Eucommia extract - chlorogenic acid (5%-98%), ursolic acid (25%-98%), corosolic acid (1%-98%), bitter amygdalin (50%-98%), epimedoside (10%-98%) and other standardized high-purity plant extracts.
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