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Asiaticoside
madecassic acid
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centella asiatic extract 

Centella Asiatic extract

Product Name: Gotu Kola Extract

Latin Name: Centella Asiatica(L.) Urban

Product Specification:

Total Triterpenoid glycosides  10%- 80%

Madecassoside 90%-95%

Asiaticoside(s) 10%, 20%, 30%, 40%, 50%, 60%, 90% , 95%HPLC

Madecassic Acid   95%

Asiatic Acid 95% HPLC

Product Type: Green Brown Powder

Part of the Plant Used: Herb(Dried, 100% Natural)

Extract Method: Grain Alcohol/water

Centella asiatica extract(Asiatic acid),also known as the thunder root, copper coin grass, horseshoe grass, is the umbrella plant Centella asiatica whole grass.The main active components of asiaticoside, hydroxy asiaticoside, cyperus oxalic acid and hydroxy cyperus oxalic acid.Centella asiatica has long been used as a brain tonic, diuretic, adjunct to leprosy, ulcer and skin diseases.Cosmetics are generally made from its dried whole grass.

 

Gotu Kola (Centella asiatica) is a smallherbaceous annual plant of the family Mackinlayaceae or subfamily

Mackinlayoideae of family Apiaceae, and is native to India, Sri Lanka, northern Australia, Indonesia, 

Iran,Malaysia, Melanesia, Papua New Guinea, and other parts of Asia. It is used as amedicinal herb in 

Ayurvedic medicine, traditional African medicine, and traditional Chinese medicine. Botanical synonyms 

include Hydrocotyle asiatica L. and Trisanthus cochinchinensis (Lour.).

 

Brief Information of Gotu Kola Extract: 

Product Name: Gotu Kola Extract

Latin Name: Centella Asiatica(L.) Urban

Product Specification:

Total Triterpenoid glycosides  10%- 80%

Madecassoside 90%-95%

Asiaticoside(s) 10%, 20%, 30%, 40%, 50%, 60%, 90% , 95%HPLC

Madecassic Acid   95%

Asiatic Acid 95% HPLC

Product Type: Green Brown Powder

Part of the Plant Used: Herb(Dried, 100% Natural)

Extract Method: Grain Alcohol/water

 

Active Ingredient: Asiaticoside

CAS No. : 16830-15-2

Molecular Formula : C48H78O19

 

Active Ingredient: Madecassoside

CAS No. : 34540-22-2

Molecular Formula : C48H78O20

 

Function:

1.Gotu Kola Extract has function of hearing heat and detoxicating,

2.Gotu Kola Extract can induce diuresis and reduce edema.

3.Gotu Kola Extract has function of brain refreshing.

4.Gotu Kola Extract has the function of nourishing,  diminish inflammation,  heal wounds or ulcers,  diuresis purge and calming.

5.Gotu Kola Extractcan can also treat leprosy, ulcer.

6.Gotu Kola Extract has wave action to blood purification and immunity.

7.Gotu Kola Extract is a very good Nerve tonic, could improve memory, reduce mental fatigue;

8.Gotu Kola Extract can reduce blood press, treat liver disease.

9.Gotu Kola Extract has function of antibacterial action.

 

Application:

1.Cosmetic Raw material

2.Healthcare Raw material

 

For more product information pls contact email sales09@staherb.cn

 

Specification

ITEAMS

SPECIFICATIONS TEST

METOODS

Aspects

Fine powder hygorscopicity

Visual

Odor

Characteristic

Organoleptic

Color

Brown to white powder

Visual

Taste

Characteristic

Organoleptic

Mesh Size

Size 95%pass 100 mesh

Sieving

Bulk Density

Density 45_65g/100ml

Density Tester

Loss on Drying

On Drying≤5.0%

5g/105c/2hrs

Ash

<5.0%

2g/525c/3hrs

Identification

Conforms

CP2010&TLC

Heavy Metals

<10ppm

CP2010

Arsenic(As)

<2ppm

GB/T5009.11-1996

Cadmium(Cd)

<1ppm

GB/T5009.15-1996

Mercury(Hg)

<0.3ppm

GB/T5009.17-1996

Lead(Pb)

<2ppm

GB/T5009.12-1996

Solvent Residues

<0.05

CP2010

Total aerobic count

<1000cfu/gram

CP2010

Total Yeast& Mold

<1000cfu/gram

CP2010

Staphylococcus aureus

Negative

CP2010

E.Coli

Negative

CP2010

Salmonella

Negative

CP2010

References:

 

  1. 1.Berg, J., T. John, and L. Stryer. 2001. Biochemistry. Freeman WH and Co., New York 

  2. 2.Bonfill, M., S. Mangas, R.M. Cusidü, L. Osuna, M.T. Piñol, and J. Palazün. 2006. Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry. Biomed. Chromatogr. 20:151–153. 

  3. 3.Bonner, J. 1972. The isoprenoids, p. 665–690. In: J. Bonner and J.E. Varner (eds.). Plant biochemistry. Academic Press, New York.

  4. 4.Gunther. B. and H. Wagner. 1996. Quantitative determination of triterpenes in extracts and phytoparations of Centella asiatica (L.) Urban. Phytomedicine 3:59–65. 

  5. 5.Hsu, Y.L., P.L. Kuo, L.T. Lin, and C.C. Lin. 2005. Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. J. Pharmacol. Exp. Ther. 313:333–344.

  6. 6.Inamdar, P.K., R.D. Yeole, A.B. Ghogare, and N.J. Souza. 1996. Determination of biologically active constituents in Centella asiatica. J. Chromatogr. A 742:127–130.

  7. 7.Jian, Z., L.C. Davis, and R. Verpoorte. 2005. Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol. Adv. 23:283–333.

  8. 8.Joshi, S.G. 2000. Medicinal plants. Oxford & IBH Publishing Co., Pvt, Ltd., New Delhi, India.

  9. 9.Kiong, A.L.P., M. Mahmood, N.M. Fadzillah, and S.K. Daud. 2005. Effects of precursor supplementation on the production of triterpenes by Centella asiatica callus cultures. Pak. J. Biol. Sci. 8:1160–1169

  10. 10.Memon, A.R., Q.Y. Chen, and W.F. Boss. 1989. Inositol phospholipids activate plasma membrane ATPase in plants. Biochem. Biophys. Res. Commun. 162:1295–1301 

  11. 11.Nelson, D.L. and M.M. Cox. 2001. Lehninger’s principles of biochemistry. Freeman WH and Co., New York. p. 1040–1059.

  12. 12.Park, B.C., K.O. Bosire, E.S. Lee, Y.S. Lee, and J.A. Kim. 2005. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 218:81–90.

  13. 13.Perassolo, M., C. Quevedo, V. Busto, F. Ianone, A.M. Giulietti, and J. Rodriguez Talou. 2007. Enhance of anthraquinone production by effect of proline and aminoindan-2-phosphonic acid in Rubia tinctorum suspension cultures. Enzyme Microb. Technol. 41:181–185. 

  14. 14.Schaneberg, B.T., J.R. Mikell, E. Bedir, and I.A. Khan. 2003. An improved HPLC method for quantitative determination of six triterpenes in Centella asiatica extracts and commercial products. Pharmazie 58:381–384.

  15. 15.Seidel, V., J. Windhövel, G. Eaton, A.W. Alfermann, R.R. Arroo, M. Medarde, M. Petersen, and J.G. Woolley. 2002. Biosynthesis of podophyllotoxin in Linum album cell cultures. Planta. 215: 1013–1039. 

  16. 16.Singh, B. and R.P. Rastogi. 1969. A re-investigation of the triterpenes of Centella asiatica. Phytochemistry 8:917–921. 

  17. 17.Sumaryono, W., P. Proksch, T. Hartmann, M. Nimtz, and V. Wray. 1991. Induction of rosmarinic acid accumulation in cell suspension cultures of Orthosiphon aristatus after treatment with yeast extract. Phytochemistry 30:3267–3271. 

  18. 18.Suzuki, T., H. Mori, T. Yamame, and S. Shimuzu. 1985. Automatic supplementation of minerals in fed-batch culture to high cell mass concentration. Biotech. Bioeng. 27:192–201. 

  19. 19.Yan, Q., Z.D. Hu, and J.Y. Wu. 2006. Synergistic effects of biotic and abiotic elicitors on the production of tanshinones in Salvia miltiorrhiza hairy root culture. China. J. Chin. Mater. Med. 31:188–191. 

  20. 20.Zhang, C., Q. Yan, W.K. Cheuk, and J. Wu. 2004. Enhancement of tanshinone production in Salvia miltiorrhiza hairy root culture by Ag+ elicitation and nutrient feeding. Planta Med. 70:147–151. 

  21. 21.Zhao, J., L.C. Davis, and R. Verpoorte. 2005. Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol. Adv. 23:283–333. 


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