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Dihydromyricetin
Myricetin
Luteolin
amygdalin
Chlorogenic acid
apigenin
Magnolia bark extract
magnolol
Honokiol
magnolol+honokiol
Macleaya cordata extract
sanguinarine
Chelerythrine
rosemary leaf extract
rosmarnic aicd
Carnosic acid
Ursolic acid
carnosic acid liquid oil
green coffee bean extract
honeysuckle flower extract
Banaba leaf extract
Loquat leaf extract
Fisetin
Polydatin
mangiferin
Betulin
huperzine a
Ferulic acid
Resveratrol

magnolol+honokiol 

magnolol+honokiol

Product Name: Magnolia Bark Extract

Botanical Source: Magnolia officinalis Rehd.et Wils.

Part Used: Bark

Active Ingredient: honokiol / Magnolol/magnolol+honokiol

Appearance: Yellow- Brown Powder to white powder

Specification:1-98%

Test Method:HPLC

magnolol and honokiol are the two main active ingredients of traditional Chinese medicine Magnolia, and have a wide range of pharmacological effects such as antibacterial, anti-inflammatory, anti-tumor muscle relaxation,cholesterol reduction and anti-aging. As early as 1930, Japan’s Sugiyra first isolated magnolol from the bark of Chinese magnolia, and proved that this ingredient is also contained in Japanese magnolia, but the amount is very low. In 1973, Fujita successively isolated magnolol and its isomers and magnolol from Japanese Magnolia and Magnolia.

 

 

Effects on the digestive system

The extract of magnolia officinalis officinalis could inhibit the formation of salt-acid ulcer in mice. Honokiol, the active ingredient of Magnolol, can inhibit gastric acid secretion and resist ulcer. Magnolol can obviously fight diarrhea in sensene-leaved mice and promote bile flow in rats, indicating that Magnolol can promote digestive system as well as wenli medicine. Magnolia officinalis treating food, cold and damp dysentery, temperature in pain.

 

Analgesic and anti-inflammatory pharmacological effects

Magnolia officinalis is an aromatic and wet herb with analgesic and anti-inflammatory activities. Magnolia officinalis ethanol extract 5g/kg and 15g/kg have significant analgesic effects, significantly reduce the increase of capillary permeability in the abdominal cavity of mice caused by acetic acid, and significantly inhibit the ear swelling of mice caused by xylene and the paw swelling of mice caused by carrageenin. The experiment shows that magnolia officinalis has obvious anti-inflammatory and analgesic effects.

 

Central and peripheral muscle relaxation and antispasmodic effect

Magnolia officinalis is often used for extreme nervous, excited state and cause unknown vibration. Magnolol, the extract of magnolia officinalis, has the effect of blocking neuromuscular junction and can induce the central muscle relaxation similar to that of myophenol. And honokiol have sedative and anti-anxiety effects. At ultra-high doses, beta eucalyptus alcohol and diphenyl ethyl ureide sodium showed stronger effects in preventing electroconvulsive seizures. It is expected that beta eucalyptus alcohol can be used as a synergistic therapy in antiepileptic therapy or antiepileptic therapy with diphenyl ethyl ureide sodium.

 

Magnolia bark extract

Active    

ingredients

Specs

Test Method

Appearance

Solubility

Magnolol

5-98%

HPLC

light yellow to white                  powder

   Soluble in        Organic      solvents

 

Honokiol

5-98%

HPLC

light yellow to white     powder

Magnolol+honokiol

5-98%

HPLC

light yellow to white     powder

Magnolia oil

 

 

Brown liquid

 

 

 

Staherb Magnolol and honokiol main function:


-Magnolol and Honokiol can alleviate anxiety, improve sleep and relieves insomnia, and cure the habit of tobacco.

-Magnolol and Honokiol has the function of anti-tumo,anti-inflammatory.

-Magnolol and Honokiol also has effect on anti-canker,and anti-dental caries and anti-periodontal disease.

 

 

Staherb Magnolol and honokiol application:

 

(1). As the medicine of anti-inflammatory, antibacterial, antioxidant and anti-tumor drug, it is widely used in the fields of medicine and health products;

 

(2). As a strong antioxidant, it is widely used in cosmetics industry-Magnolol is powerful antioxidant in cardiovascular diseases.

 

 

Why choose STAHERB for Magnolia Bark Extract(magnolol,honokiol,magnolol+honokiol)

 

1. Founded in 2010, Changsha staherb natural ingredients co.,ltd is a professional standardized plant extract manufacturer.

2.Hunan is the origin of Magnolia officinalis. Hunan is the most important production base of Magnolia officinalis in China. It is rich in wild resources. Changsha staherb and the local farmers have built a planting base of Magnolia officinalis with sufficient raw materials. Changsha staherbs  Magnolia production workshop is located in the raw material base, with better quality control of raw materials, lower production cost and better price.

3.Magnolia officinalis extract is the main product of Changsha Staherb, which is produced throughout the year, with stable quality and spot supply.

4.Staherb has a complete set of quality testing equipment and system, quality assurance.

5.The Magnolia officinalis extract of Staherb is produced by supercritical CO2 extraction technology, with large production and good quality control. No organic reagent is used in the extraction process, so the product quality is better and safer

6.Staherb Magnolia extract series products include: Magnolia+honokiol 1-98%, Magnolol 1-98%, and honokiol 1-98%, magnolia oil, magnolia oil extract, etc., full specifications products to meet your need.

 

For more product information pls contact email sales09@staherb.cn

 

Reference:

1.Reiss, U., and D. Gershon, Comparison of Cytoplastic Superoxide Dismutase in Liver. Heart and Brain of Aging Rats and Mice, Biochem. Biophys. Res. Commum. 73:255–262 (1976).
2.Schultze-Osthoff, K., A.C. Bakker, B. Vanhaesebroeck, R. Beyaert, W.A. Jacob, and W. Fiers, Cytotoxic Activity of Tumor Necrosis Factor Is Mediated by Early Damage of Mitochondrial Functions, J. Biol. Chem. 267:5317–5323 (1992).
3.Bragt, P.C., J.I. Bansberg, and I.L. Bonta, Antiinflammatory Effects of Free Radical Scavengers and Antioxidants, Inflammation 4:289–299 (1980).
4.Fong, L.G., S. Parthasarathy, J.L. Witzum, and D. Steinberg, Nonenzymatic Oxidative Cleavage of Peptide Bonds in Apoprotein B-100, J. Lipid Res. 28:1466–1477 (1987).
5.Urano, S., M. Hoshi-Hashizume, N. Tochigi, M. Matsuo, M. Shiraki, and H. Ito, Vitamin E and the Susceptibility of Erythrocytes and Reconstituted Liposomes to Oxidative Stress in the Aged Diabetics, Lipids 26:58–61 (1976).
6.Marubayashi, S., K. Dohi, K. Yamada, and T. Kawasaki, Changes in the Liver of Endogenous Coenzyme Q Homologs, α-Tocopherol, and Glutathione in Rat Liver After Hepatic Ischemia and Reperfusion, and The Effect of Pretreatment with Coenzyme Q10, Biochim. Biophys. Acta 797:1–9 (1984).
7.Antioxidants-Free Radical and Biological Defence, edited by Niki, E., H. Shimaski, and M. Mino, Gakkai-Syuppan Center, Tokyo, 1994, pp. 3–16.
8.Okuda, T., Y. Kimura, T. Yoshida, T. Hatano, H. Okuda, and S. Arichi, Studies on Activities of Tannins and Related Compounds from Medical Plants and Drugs. I. Inhibitory Effects on Lipid Oxidation in Mitochondria and Microsomes of Liver, Chem. Pharm. Bull. 31:1625–1631 (1983).
9.Yoshikawa, T., S. Takahashi, and M. Kondo, Oxygen-Derived Free Radical and Traditional Kampo Medicines, Recent Adv. Cardiopathy Diseases XII:173–181 (1991).
10.Urano, S., M. Iida, I. Otani, and M. Matsuo, Membrane Stabilization of Vitamin E: Interaction of α-Tocopherol with Phospholipids in Bilayer Liposomes, Biochem. Biophys. Res. Commun. 146:1413–1418 (1976).
11.Fukuzawa, K., H. Chida, A. Tokumura, and H. Tsukatani, Antioxidative Effects of α-Tocopherol Incorporation into Lecithin Liposomes on Ascorbic Acid-Fe2+-Induced Lipid Peroxidation, Arch. Biochem. Biophys. 206:173–180 (1981).
12.Yahara, S., T. Nishiyori, A. Kohdo, T. Nohara, and I. Nishioka, Isolation and Characterization of Compounds from Magnolia cortex Produced in China, Chem. Pharm. Bull. 34:2024–2036 (1991).
13.Hattori, M., M. Tsunezuku, S. Kadota, T. Kikuchi, and T. Namba, Studies on Dental Caries Prevention by Traditional Chinese Medicine. Part V. A Comparison of Antibacterial Action of Magnolol, Honokiol and Related Compounds Against Streptococcus mutans, Shoyakugaku Zasshi 39:76–79 (1985).
14.Kitagawa, S., H. Fujisawa, and H. Sakurai, Scavenging Effects of Dihydric and Polyhydric Phenols on Superoxide Anion Radicals, Studied by Electron Spin Resonance Spectrometry, Chem. Pharm. Bull. 40:304–307 (1992).
15.Robak, J., and R.J. Gryglewski, Flavonoids Are Scavengers of Superoxide Anions, Biochem. Pharmacol. 37:837–841 (1988)
16.Fuzita, Y., K. Togawa, T. Yoshida, T. Hatano, and T. Okuda, Antioxidant Mechanism by Tannins and Flavonoids, Wakan Iyakugaku Zasshi (Japan) 2:647–675 (1985).
17.Antioxidant activity of Magnolol, honokiol, and related phenolic compounds
The antioxidant activity of 10 Japanese and Chinese crude drugs (Kampo drugs) was determined in vitro. Extract of Magnolia cortex, which had the highest antioxidant activity, contained phenolic compounds magnolol...

Masahiro Ogata, Midori Hoshi… in Journal of the American Oil Chemists' Soci… (1997)

18.Variation, heredity and selection of effective ingredients inMagnolis officinalis of different provenances
Bark samples ofMagnolis officinalis were collected from a 7-year-old trial plantation with 13 provenances in Jingning County of Zhejiang Province on June 25, 2000. The contents of magnolol and honokiol ofM. offic...
Tong Zai-kang, Zeng Yan-ru, Si Jin-ping in Journal of Forestry Research (2002)

19.High-Performance Thin-Layer Chromatographic-Bioautographic Method for the Simultaneous Determination of Magnolol and Honokiol in Magnoliae officinalis Cortex
A simple and accurate high-performance thin-layer chromatography (HPTLC)-bioautographic method was developed for the quantitative analysis of magnolol and honokiol in the herbal medicine Magnoliae officinalis Cor...

Lihua Gu, Shansong Zheng, Tao Wu… in JPC – Journal of Planar Chromatography – M… (2014)

20.Eugenol and Its Role in Chronic Diseases
The active components in cloves are eugenol and isoeugenol. Eugenol has recently become a focus of interest because of its potential role in alleviating and preventing chronic diseases such as cancer, inflamma...
S. Fujisawa, Y. Murakami in Drug Discovery from Mother Nature (2016)

21.Cardiovascular protection of magnolol: cell-type specificity and dose-related effects
Magnolia officinalis has been widely used in traditional Chinese medicine. Magnolol, an active component isolated from Magnolia officinalis, is known to be a cardiovascular protector since 1994. The multiplex mec...

Jennifer Hui-Chun Ho, Chuang-Ye Hong in Journal of Biomedical Science (2012)

22.Anti-platelet effect of the constituents isolated from the barks and fruits ofMagnolia obovata
In the course of our work on anti-platelet constituents from plants, five phenolic compounds, mag-nolol, honokiol, obovatol, methyl caffeate, and syringin, were isolated from the methanol extracts of the barks...

Mi Kyung Pyo, YongYook Lee, Hye Sook Yun-Choi in Archives of Pharmacal Research (2002)

23.Magnolia grandiflora
Tong Kwee Lim in Edible Medicinal and Non Medicinal Plants (2014)

24.Antimicrobial activities of hydroxybiphenyl derivatives (I)
It was revealed that magnolol and honokiol isolated from the stem bark ofMagnolia obovata, had potent antibacterial activity againstBacillus anthracis. A quantitative analytical method of magnolol and honokiol by...

Kihwan Bae, Beongtae Yoo, Myungkoo Lee, Wonjun Seo in Archives of Pharmacal Research (1985)


25.Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity
Magnolol, honokiol, and obovatol are well-known bioactive constituents of the bark of Magnolia officinalis and have been used as traditional Chinese medicines for the treatment of neurosis, anxiety, and stroke. W...

Yong Kyung Lee, Dong Yeon Yuk, Tae Il Kim, Young Heui Kim… in Journal of Natural Medicines (2009)

26.Neuroprotective Herbs for Stroke
In recent years, many attempts have been made to document research data from extracts of composite formulas, single herbs, or single compounds from traditional Eastern medicine (TEM) herbs, according to orthod...

Hocheol Kim in Herbal Drugs: Ethnomedicine to Modern Medicine (2009)

27.Additivities of Compounds that Increase the Numbers of High Affinity [3H]Muscimol Binding Sites by Different Amounts Define More than 9 GABAA Receptor Complexes in Rat Forebrain: Implications for Schizophrenia and Clozapine Research
Background

Richard Felt Squires, Else Saederup in Neurochemical Research (2000)

28.Distinct Photoacidity of Honokiol from Magnolol
Honokiol, 5,5′-diallyl-2,4′-dihydroxy- biphenyl, by comparison with its isomer magnolol, 5,5′-diallyl- 2,2′-dihydroxy- biphenyl, has been characterized by steady-state and time-resolved spectroscopy as well as 1H...

Hongmei Li, Xianfeng Wang, Yuzhu Hu in Journal of Fluorescence (2011)

29.Antioxidant activity of the different polar solvent extracts of Magnolia officinalis leaves and purification of main active compounds
The leaf of Magnolia officinalis is abundant in natural resources as a novel potential antioxidant and has great commercial value. In this study, the contents of total phenolics, total flavonoids, magnolol and ho...

Li-Hong Tan, Dan Zhang, Bao Yu, Sheng-Ping Zhao… in European Food Research and Technology (2015)


30.Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia
Eight medicinal plants were tested for their antimicrobial and antioxidant activities. Different extraction methods were also tested for their effects on the bioactivities of the medicinal plants.

Lai Wah Chan, Emily LC Cheah, Constance LL Saw, Wanyu Weng… in Chinese Medicine (2008)

31.Methylation and Esterification of Magnolol for Ameliorating Cutaneous Targeting and Therapeutic Index by Topical Application
As a continuing effort to elucidate the impact of structure modification upon cutaneous absorption behavior, we attempted to assess the skin permeation of magnolol by methylation and acetylation.
Chwan-Fwu Lin, Chi-Feng Hung, Ibrahim A. Aljuffali… in Pharmaceutical Research (2016)

32.Variation in the microbial community contributes to the improvement of the main active compounds of Magnolia officinalis Rehd. et Wils in the process of sweating
Magnolia officinalis Rehd. et Wils, commonly called Houpo, has been used for thousands of years in China as a traditional herbal medicine. The primary processing of Houpo requires sweating treatment, which is a s...

Qinahua Wu, Dan Wei, Linlin Dong, Yuping Liu, Chaoxiang Ren… in Chinese Medicine (2019)

33.Cortex Magnoliae officinalis Houpo
Prof.em.Dr.Dr.h.c.mult. Hildebert Wagner… in Chromatographic Fingerprint Analysis of He… (2011)

34.Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts
Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson’s disease (PD), multiple system atrophy, a...

Mustafa T. Ardah, Simona S. Ghanem… in BMC Complementary Medicine and Therapies (2020)

35.Quantitative Structure–Activity Relationships of Antimicrobial Compounds
A thorough antimicrobial review of an increasing number of reports reveals a broad spectrum of research activity in the development practices that are used to treat a variety of diseases. The quantitative rela...
F. P. Maguna, N. B. Okulik, Eduardo A. Castro in Handbook of Computational Chemistry (2017)

36.Peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plantsWe determined the ability of extracts and active components isolated from nine medicinal plants, Poncirus trifoliata, Astragalus membranaceus, Magnolia obovata, Salvia miltiorrhiza, Angelica dahurica, Cornus offi...

Sun Ju Kim, Do Young Kwon, Yeong Shik Kim, Young Chul Kim in Archives of Pharmacal Research (2010)


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