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藤茶提取物二氢杨梅素 Dihydromyricetin
杨梅素 Myricetin
木犀草素Luteolin
苦杏仁甙amygdalin
绿原酸Chlorogenic acid
芹菜素apigenin
厚朴提取物Magnolia bark extract
厚朴酚magnolol
和厚朴酚Honokiol
厚朴总酚magnolol+honokiol
博落回提取物Macleaya cordata extract
血根碱sanguinarine
白屈菜红碱Chelerythrine
迷迭香提取物rosemary leaf extract
迷迭香酸rosmarnic aicd
鼠尾草酸Carnosic acid
熊果酸Ursolic acid
鼠尾草酸油carnosic acid liquid oil
绿咖啡豆提取物green coffee bean extract
金银花提取物honeysuckle flower extract
巴拿巴叶提取物Banaba leaf extract
枇杷叶提取物Loquat leaf extract
漆黄素Fisetin
虎杖甙Polydatin
芒果甙mangiferin
白桦脂醇Betulin
石杉碱甲huperzine a
阿魏酸Ferulic acid
白藜芦醇Resveratrol

杨梅素 Myricetin 

杨梅树皮提取物杨梅素

来源: 杨梅树皮

拉丁名: Myrica rubra (Lour.) Sieb. et Zucc

提取部位: 杨梅树皮

规格: 3%-98%

有限成份:杨梅素

CAS号:529-44-2

检测方式:HPLC

颜色: 黄绿色

 

梅素又称杨梅树皮素、杨梅黄酮,是从杨梅科(Myricaceae)植物杨梅的树皮中提取的一种黄酮醇类化合物。杨梅是原产中国的亚热带果树之一,野生种生长史已有7000多年,人工栽培已有2000多年。我国华东和湖南、广东、广西、贵州等地区具有极为丰富的杨梅树皮资源, 经过修剪丢弃的杨梅树枝可做为长期大量的植物来源。但是, 由于提取工艺等原因,目前对杨梅素的研究主要来源于藤茶, 来源杨梅树的非常少。而藤茶中主要获得的是二氢杨梅素且资源有限, 对杨梅素的长期的开发和利用存在一定的局限性。

杨梅树皮在民间用作抗菌消炎药,杨梅树皮中主要含有杨梅素和杨梅素甙。近年来,国内外研究表明,杨梅素具有多种活性:血小板活化因子(PAF) 的拮抗作用、降血糖作用、抗氧化作用、保肝护肝作用、解轻乙醇中毒、杨梅树皮和树叶中的活性成分杨梅素除具有上述已经验证的药理作用外,还具有抗炎、抗肿瘤、抗突变、预防龋齿、抗氧化性、消除体内自由基等多种药理活性。

杨梅素的功效和应用

杨梅素 Myricetin主要功能:

1)抗氧化的作用:杨梅素 Myricetin是一种很强的抗氧化剂,氧化应激在各种神经疾病包括局部缺血和老年期痴呆中起关键作用。杨梅素通过构象变化作用减少β-淀粉酶的产生和毒性,可用于统计老年痴呆的进展状况。

2)抗肿瘤作用:杨梅素 Myricetin是一种有效的致癌作用化学防治剂。

3)降低神经毒性:杨梅素 Myricetin可以通过不同途径抑制由谷氨酸引起的神经毒性保护神经元,从而有效阻止神经损伤。

4)对淋巴细胞活化及增殖的影响:杨梅素 Myricetin能抑制T细胞早期活化指标CD69的表达,并能抑制淋巴细胞增殖反应。

5)血小板活化因子(PAF)的拮抗作用:杨梅素体外呈浓度依赖性地抑制PAF诱发的WRP聚集及52HT释放。同时能明显抑制PAF引起的血小板内游离钙的增高。因此杨梅素具有抗血栓、抗心肌缺血、改善微循环等多方面的心血管药理作用。

6)降血糖作用:杨梅素 Myricetin具有较为明显的降血糖作用。

7)保肝护肝的作用:杨梅素能明显抑制血清中丙氨酸转氨酶(ALT)和天冬氨酶转氨酶(AST)的活性升高及降低血清总胆红素,有明显的降酶退黄的作用。

标 题HPLC法测定二氢杨梅素含量的操作规程

起草单位:长沙上禾生物科技有限公司

目  的:HPLC法测定二氢杨梅素含量的操作规程

责任人:QC员。

内  容:

1、 试剂

1.1 甲醇(HPLC级)

1.2 蒸馏水(AR级)

1.3冰醋酸(HPLC级)

2、 对照品

二氢杨梅素(购自中国药品生物制品检定所)

3、 仪器和用具

3.1 电子天平(1/100000)

3.2 玻璃仪器:100ml容量瓶

3.3 安捷伦1220 HPLC

4、液相条件

4.1流动相:甲醇:水:冰醋酸=50:50:1

4.2检测波长:292nm

4.3流速:1ml/min

4.4柱温:30℃

5 、  操作步骤

5.1 对照品溶液的制备  精密称取在110℃干燥至恒重的二氢杨梅素对照品10mg,置50ml容量瓶中,加50%甲醇适量,超声处理10min使溶解,放冷,加50%甲醇至刻度,摇匀,备用。

 5.2样品溶液制备  精密称取在110℃干燥至恒重的二氢杨梅素样品10mg,置50ml容量瓶中,加50%甲醇适量,超声处理10min使溶解,放冷,加50%甲醇至刻度,摇匀,备用。

6、检测

取对照品溶液和样品溶液0.22μm针孔过滤器过滤,进样20µl,根据峰面积计算样品含量。

含量按以下公式计算:

         A2 x C1 x T

  R=----------------- x 100

    A1 x C2

C1: 对照品的参考浓度,mg/ml

C2: 样品的参考浓度,mg/ml

A1: 对照品溶液的色谱主峰值面积

A2: 样品溶液的色谱主峰值面积

T:  对照品的含量

 

参考文献:

1.A. Umarov, V.S. Batyk, A.M. Khaleckii, Chem. Nat. Comp. 7, 499 (1971)

2.V.A. Soboleva, R.K. Chagovets, Chem. Nat. Comp. 7, 509 (1971)

3.R.K. Chagovets, I.M. Persev, V.O. Soboleva, Farm. Zh. 22, 64 (1967)

4.O.M. Bondarenko, R.K. Chagovets, V.I. Litvinenko, G.V. Obolensova, B.I. Sila, T.B. Kigel, Farm. Zh. 26, 46 (1971)

5.K. Miller, R. Pohl, Planta Med. 18, 114 (1970)

6.V.A. Soboleva, R.K. Chagovets, O.I. Gladkaya, //In proceeding: Tez 2-go simpoziuma po fenolnim soedineniyam., (Alma-Ata, 1970), p. 148

 7.Effects of myricetin on the bioavailability of doxorubicin for oral drug delivery in Rats: Possible role of CYP3A4 and P-glycoprotein inhibition by myricetin
The purpose of this study was to investigate the effect of oral myricetin on the bioavailability and pharmacokinetics of orally ... rats for oral delivery. The effect of myricetin on the P-glycoprotein (P-gp) and...

Sang-Joon Choi, Sang-Chul Shin, Jun-Shik Choi in Archives of Pharmacal Research (2011)

8.A glycoside of myricetin from the flowers of Hibiscus cannabinusZ. P. Pakudina, B. Maksudova in Chemistry of Natural Compounds (1976)

Für die elektrophoretische Auftrennung und densitometrische Bestimmung der Flavonoide Kämpferol (1), Quercetin (2), Quercetagerol (3), Myricetin (4) und der Heteroside Robinosid (5), Quercitrosid (6), Isoquercitrosid (7), Rutosid (8) und Myricitrosid (9)
K. Söllner in Fresenius' Zeitschrift für analytische Chemie (1960)

9.Evaluation of the antioxidant potential of myricetin 3-O-α-L-rhamnopyranoside and myricetin 4′-O-α-L-rhamnopyranoside through a computational study
In this work, we present a computational study on the antioxidant potential of myricetin 3-O-α-L-rhamnopyranoside (Compound M3) and myricetin 4′-O-α-L-rhamnopyranoside (Compound M4′). Structural parameters, bond ...
Rodrigo A. Mendes, Shawan K. C. Almeida, Iuri N. Soares… in Journal of Molecular Modeling (2019)


10.Spektrophotometrische und fluorometrische Bestimmung von Myricetin (3,3′,4′,5,5′,7-Hexahydroxy-Flavon)
Myricetin (3,3′,4′,5,5′,...−4% Myricetin lassen sich mit einem relativen Fehler von...
Antonia S. Zaprjanowa in Microchimica Acta (1976)


11.Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves
Myrica rubra Sieb. et Zucc....leaves are commonly used as an astringent, antidiarrheic, and analgesics in folk medicine in China. In the present study, the analgesic activity of myricetin

Yan Tong, Xiao-Mian Zhou, Shu-Jun Wang, Yang Yang… in Archives of Pharmacal Research (2009)


12.Inhibition of interleukin-12 production in mouse macrophagesvia decreased nuclear factor-κB DNA binding activity by myricetin, a naturally occurring flavonoid
Pharmacological inhibition of interleukin-12 (IL-12) production may be a therapeutic strategy for preventing the development and progression of disease in experimental models of autoimmunity. In this study, the e...

Bok Yun Kang, Seung Hyun Kim, Daeho Cho, Tae Sung Kim in Archives of Pharmacal Research (2005)


13.Protective functions of myricetin in LPS-induced cardiomyocytes H9c2 cells injury by regulation of MALAT1
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a crucial mediator in response to inflammation. Myricetin protects cardiomyocytes against inflammatory injury. However, it’s still unexplored whe...

Jinliang Sun, Jianhui Sun, Xuezhong Zhou in European Journal of Medical Research (2019)

 

14.A DFT-based study of the hydrogen-bonding interactions between myricetin and ethanol/water
Flavonoids are vital constituents of propolis that are responsible for its medicinal activity. Flavonoid extraction commonly employs ethanol and water as solvents. In the extraction reaction, hydrogen-bonding int...

Yan-Zhen Zheng, Geng Deng, Rui Guo, Da-Fu Chen, Li-Ming Wu in Journal of Molecular Modeling (2019)


15.Validated HPTLC Method for Quantification of Myricetin in the Stem Bark of Myrica esculenta Buch. Ham. Ex D. Don, Myricaceae
A simple, rapid, and precise high-performance thin-layer chromatographic method has been established for quantitative analysis of myricetin in the stem bark of Myrica esculenta, family Myricaceae. The marker myricetin

Kalpana G. Patel, Vandana G. Patel… in JPC – Journal of Planar Chromatography – M… (2010)

 

16.Effects of myricetin, an anticancer compound, on the bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats
This study examined the effect of myricetin, an anticancer compound, on the bioavailability ... 4-hydroxytamoxifen, in rats. The effect of myricetin on P-glycoprotein (P-gp), cytochrome ... (CYP)3A4 and 2C9 activ...

Cheng Li, Sung-Cil Lim, Jin Kim… in European Journal of Drug Metabolism and Ph… (2011)


17.Enhancement of recombinant myricetin on the radiosensitivity of lung cancer A549 and H1299 cells
Myricetin, a common dietary flavonoid is widely distributed ... this study was to investigate the effects of myricetin on combination with radiotherapy enhance radiosensitivity of...

Shijie Zhang, Lei Wang, Hongchun Liu, Guoqiang Zhao, Liang Ming in Diagnostic Pathology (2014)


18.Metabolite Identification of Myricetin in Rats Using HPLC Coupled with ESI-MS Myricetin, a naturally occurring flavonol, shows multifarious ... In order to obtain an understanding of the myricetin’s metabolism in vivo, a rapid and... n ...) techniques was ...

Yun Lin, Bin Wu, Zhixiong Li, Ting Hong, Mingcang Chen, Yingzi Tan… in Chromatographia (2012)

 

19.Thermochemistry of myricetin flavonoid The enthalpies of myricetin dissolution are measured by means of calorimetry...

A. Z. Abil’daeva, Sh. B. Kasenova, B. K. Kasenov… in Russian Journal of Physical Chemistry A (2014)

20.The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro Plant extracts are sources of valuable compounds with biological activity, especially for the anti-proliferative activity against pathogens or tumor cells. Myricetin is a flavonoid found in several plants ... act...

Joseph T. Ortega, Alirica I. Suárez, Maria L. Serrano… in AIDS Research and Therapy (2017)


21.Anti-inflammatory activity of myricetin-3-O-β-D-glucuronide and related compounds Objective and Design: The anti-inflammatory effect of myricetinglucuronide (MGL) was investigated and structurally-related compounds were compared to examine the structure/activity-relationship ...

A. Hiermann, H. W. Schramm, S. Laufer in Inflammation Research (1998)


22.Chemical modification of the natural flavonoid myricetin A review is presented of our own results on the synthesis of nitro-, amino-, azo-, and bromo- derivatives of myricetin, as a result which 19 new derivatives...

V. V. Polyakov in Chemistry of Natural Compounds (1999)


23.Antioxidant properties of myricetin and quercetin in oil and emulsions
The effect of quercetin and myricetin on the stability of sunflower oil and ... , conjugated dienes, and headspace volatile analysis. Myricetin showed strong antioxidant activity in oils stored ... tocopherols an...

Andrea Roedig-Penman, Michael H. Gordon in Journal of the American Oil Chemists' Society (1998)


24.Integrative analysis of miRNA and mRNA profiles in response to myricetin in human endothelial cells
MicroRNAs (miRNAs) are associated with a diverse range of biological processes, human diseases, and metabolic disorders. Myricetin, which is the most abundant polyphenol class ... . The present study aimed to eva...

Seung Eun Lee, Gun Woo Son, Hye Rim Park, Young-Ho Jin, Cheung-Seog Park… in BioChip Journal (2015)


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