Camptothecin is a plant secondary metabolite used as an anti-cancer drug that damages DNA, leading to the destruction of the cell. It comes from Camptotheca acuminata, a deciduous tree found in southern China. A close analogue, 9-methoxycamptothecin, is also present in the same source

 

Mechanism of Action:

 

Camptothecin affects the activity of the enzyme topoisomerase I, whose normal action is to cleave, unwind, and religate DNA. When camptothecin binds to topoisomerase I, it will be able to cleave but not to religate DNA. Thereby, camptothecin causes single strand breaks in DNA.

 

Camptothecin  Functions  

 

1-Camptothecin can make changes in skin epidermal keratinization process.
2-Camptothecin is used for anti-cancer, anti-virus, immune inhibition, anti early pregnancy.
3-Camptothecin has the function of treatment of gastric cancer, liver cancer, head and neck cancer and leukemia.    

 

Camptothecin Applications   

 

1.Treatment Gastrointestinal cancer and leukemia,

2.Plant growth regulator activity and kill insects. 

3.Treatment of gastric cancer, liver cancer, head and neck cancer and leukemia,, with fewer side effects than camptothecine.

 

For more product information pls contact email sales09@staherb.cn

 

Product Analysis:

 

Items	Standards	Results
Physical Analysis
Description	Light Yellow Powder	Complies
Assay	98%	98.2%
Mesh Size	100 % pass 80 mesh	Complies
Ash	≤ 5.0%	2.85%
Loss on Drying	≤ 5.0%	2.85%
Chemical Analysis
Heavy Metal	≤ 10.0 mg/kg	Complies
Pb	≤ 2.0 mg/kg	Complies
As	≤ 1.0 mg/kg	Complies
Hg	≤ 0.1 mg/kg	Complies
Microbiological Analysis
Residue of Pesticide	Negative	Negative
Total Plate Count	≤ 1000cfu/g	Complies
Yeast&Mold	≤ 100cfu/g	Complies
E.coil	Negative	Negative
Salmonella	Negative	Negative